CAJ | 학술논문

目的:研究2%利多卡因凝胶鼻腔内涂抹治疗Ⅱ支三叉神经痛的疗效.方法:20例Ⅱ支三叉神经痛的患者随机分至两组,分别在患侧鼻腔涂抹2%利多卡因凝胶2ml或生理盐水对照.7天后两组患者交换.触碰面部诱发疼痛发作,测定给药前和给药后15分钟疼痛视觉模拟评分(VAS),并记录疼痛是否再次出现以及一次给药后疼痛有效控制的持续时间.结果:利多卡因组VAS值显著下降(P<0.01),而生理盐水组无显著变化.治疗效果平均维持4.5小时(范围0.5～24小时).结论:2%利多卡因凝胶鼻腔内涂抹治疗Ⅱ支三叉神经痛能迅速显效并维持一段时间,无严重不良反应.
목적:연구2%리다잡인응효비강내도말치료Ⅱ지삼차신경통적료효.방법:20례Ⅱ지삼차신경통적환자수궤분지량조,분별재환측비강도말2%리다잡인응효2ml혹생리염수대조.7천후량조환자교환.촉팽면부유발동통발작,측정급약전화급약후15분종동통시각모의평분(VAS),병기록동통시부재차출현이급일차급약후동통유효공제적지속시간.결과:리다잡인조VAS치현저하강(P<0.01),이생리염수조무현저변화.치료효과평균유지4.5소시(범위0.5～24소시).결론:2%리다잡인응효비강내도말치료Ⅱ지삼차신경통능신속현효병유지일단시간,무엄중불량반응.
objective:To evaluate the effectiveness of intranasal lidocaine-hydrochloride-mucilage 2%on paroxysmal pain in second-division trigeminal neuralgia.Methods:Twenty patients with second-division trigeminal neuralgia were randomized to receive 2rrd of either lidocaine-hydrochloride-mucilage 2%or sa- line placebo in the affected nostril.After a 7 day period.patients were crossed over to receive the alter- native treatment.The paroxysmal pain triggered by touching was assessed with a 10 cm visual analogue scale(VAS)before and 15 min after treatment.Patients were asked to record whether the pain relieved and how long after therapy it recurred.Results:Intranasal lidocaine 2%significantly decreased VAS, whereas the placebo did not.The effect of treatment persisted for 4.5 h(range 0.5～24 h).Conclusion: Intranasal lidocaine-hydrochloride-mucilage 2%produced prompt but temporary analgesia without serious adverse reactions in patients with second-division trigeminal neuralgia.