中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2009年
18期
1-2
,共2页
超敏C反应蛋白%心肌钙蛋白I%心肌酶%缺血缺氧性脑病%新生儿
超敏C反應蛋白%心肌鈣蛋白I%心肌酶%缺血缺氧性腦病%新生兒
초민C반응단백%심기개단백I%심기매%결혈결양성뇌병%신생인
High-sensitivity C reactive protein%Cardiac troponin%Cardiac enzyme%Hypoxic ischemic encephalopathy%Newborn
目的 探讨超敏C反应蛋白(hs-CRP)、肌钙蛋白I(cTnI) 心肌酶在新生儿缺血缺氧性脑病(HIE)中的变化及其意义.方法 利用全自动生化分析仪测定35例HIE和26例正常新生儿血清hs-CRP、cTnI水平,并同时检测血清CK、CK-MB、LDH、ALT、AST.结果 HIE新生儿急性期血清hs-CRP水平明显高于对照组(P＜0.05);恢复期下降,与正常对照组差异无统计学意义(P>0.05).HIE新生儿急性期血清cTnI水平明显高于对照组(P＜0.01);恢复期cTnI与正常对照组之间无差异无统计学意义(P>0.05).HIE新生儿急性期CK、CK-MB、LDH、AST、ALT均较正常新生儿升高;恢复期CK、CK-MB、ALT降低明显(P＜0.05),与正常对照组之间差异有统计学意义(P＜0.05);LDH、AST降低不明显(P>0.05),但与正常对照组比较差异仍有统计学意义(P＜0.05).结论 hs-CRP和cTnI的动态变化与HIE的疗程相平行,能较敏感地反映HIE患儿病情程度及转归趋势,与血清酶学改变一起可作为了解HIE的疗效及病情监测的指标之一.
目的 探討超敏C反應蛋白(hs-CRP)、肌鈣蛋白I(cTnI) 心肌酶在新生兒缺血缺氧性腦病(HIE)中的變化及其意義.方法 利用全自動生化分析儀測定35例HIE和26例正常新生兒血清hs-CRP、cTnI水平,併同時檢測血清CK、CK-MB、LDH、ALT、AST.結果 HIE新生兒急性期血清hs-CRP水平明顯高于對照組(P＜0.05);恢複期下降,與正常對照組差異無統計學意義(P>0.05).HIE新生兒急性期血清cTnI水平明顯高于對照組(P＜0.01);恢複期cTnI與正常對照組之間無差異無統計學意義(P>0.05).HIE新生兒急性期CK、CK-MB、LDH、AST、ALT均較正常新生兒升高;恢複期CK、CK-MB、ALT降低明顯(P＜0.05),與正常對照組之間差異有統計學意義(P＜0.05);LDH、AST降低不明顯(P>0.05),但與正常對照組比較差異仍有統計學意義(P＜0.05).結論 hs-CRP和cTnI的動態變化與HIE的療程相平行,能較敏感地反映HIE患兒病情程度及轉歸趨勢,與血清酶學改變一起可作為瞭解HIE的療效及病情鑑測的指標之一.
목적 탐토초민C반응단백(hs-CRP)、기개단백I(cTnI) 심기매재신생인결혈결양성뇌병(HIE)중적변화급기의의.방법 이용전자동생화분석의측정35례HIE화26례정상신생인혈청hs-CRP、cTnI수평,병동시검측혈청CK、CK-MB、LDH、ALT、AST.결과 HIE신생인급성기혈청hs-CRP수평명현고우대조조(P＜0.05);회복기하강,여정상대조조차이무통계학의의(P>0.05).HIE신생인급성기혈청cTnI수평명현고우대조조(P＜0.01);회복기cTnI여정상대조조지간무차이무통계학의의(P>0.05).HIE신생인급성기CK、CK-MB、LDH、AST、ALT균교정상신생인승고;회복기CK、CK-MB、ALT강저명현(P＜0.05),여정상대조조지간차이유통계학의의(P＜0.05);LDH、AST강저불명현(P>0.05),단여정상대조조비교차이잉유통계학의의(P＜0.05).결론 hs-CRP화cTnI적동태변화여HIE적료정상평행,능교민감지반영HIE환인병정정도급전귀추세,여혈청매학개변일기가작위료해HIE적료효급병정감측적지표지일.
Objective To investigate the change and clinical significance of serum high-sensitivity C reactive protein (hs-CRP) and cardiac troponin (cTnⅠ) in newborns with hypoxic ischemic encephalopathy.Methods The serum hs-CRP,cTn, creatine kinase (CK), creatine phosphokinase iscenzyine (CK-MB), lactate dehydrogenase (LDH), alanine transaminase (ALT) and aspartate aminctransferasc (AST) were examined by reaction rate method.Results The hs-CRP in newborns with acute HIE was significantly higher than that in control group (P＜0.05), and there was no significant difference in recovery stage between two groups. The cTnI in newborns with acute HIE was significantly higher than that in control group (P＜0.05), and there was no significant difference in recovery stage between two groups. The CK、CK-MB、LDH、AST and ALT in newborns with acute HIE was significantly higher than that in control group. In recovery stage CK、CK-MB、ALT decreased significantly (P＜0.05). LDH and AST decreased insignificantly but with significant difference between two groups. Conclusions The changes of hs-CRP and cTnI in serum can reflect the disease severity and prognosis, and they are importannt for the evaluation of treatment effects of HIE.
