中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2009年
19期
49-51
,共3页
强直性脊柱炎%骨密度%尿Ⅰ型胶原C末端肽%骨特异性碱性磷酸酶%骨钙素
彊直性脊柱炎%骨密度%尿Ⅰ型膠原C末耑肽%骨特異性堿性燐痠酶%骨鈣素
강직성척주염%골밀도%뇨Ⅰ형효원C말단태%골특이성감성린산매%골개소
Ankylosing spondylitis (AS)%bone mineral density(BMD)%urinary C-terminal telopeptide fragments of type I collagen(CTX-Ⅰ)%serum bone-specific alkaline phosphatase(BALP)%serum osteocalcin(sOC)
目的 通过测定强直性脊柱炎(AS)男性患者血清骨特异性碱性磷酸酶(BALP)、血清骨钙素(sOC)、尿Ⅰ型胶原C末端肽(CTX-Ⅰ)水平,以探讨与疾病活动性、骨密度(BMD)的关系.方法 用ELISA方法 测定35名AS患者血清BALP、sOC、尿CTX-Ⅰ;用双能X线吸收法(DEXA)测定腰椎正位(AP)L1-L4总体和股骨颈的BMD,根据Bath强直性脊柱炎疾病活动指数(BASDAI)对患者病情进行评分,并与70名健康者对照.结果 AS患者尿CTX-Ⅰ水平显著高于对照组(P<0.05);直线相关显示,尿CTX-Ⅰ水平与股骨颈BMD呈负相关(r=-0.414,P<0.05),与BASDAI、C反应蛋白(CRP)呈正相关(r=0.445,P<0.05;r=0.491,P<0.01).AS患者血清BALP、sOC水平与对照组无统计学意义,且与BMD、BASDAI无明显相关性.结论 CTX-Ⅰ水平升高提示患者骨吸收增强、骨密度降低、疾病呈活动性.
目的 通過測定彊直性脊柱炎(AS)男性患者血清骨特異性堿性燐痠酶(BALP)、血清骨鈣素(sOC)、尿Ⅰ型膠原C末耑肽(CTX-Ⅰ)水平,以探討與疾病活動性、骨密度(BMD)的關繫.方法 用ELISA方法 測定35名AS患者血清BALP、sOC、尿CTX-Ⅰ;用雙能X線吸收法(DEXA)測定腰椎正位(AP)L1-L4總體和股骨頸的BMD,根據Bath彊直性脊柱炎疾病活動指數(BASDAI)對患者病情進行評分,併與70名健康者對照.結果 AS患者尿CTX-Ⅰ水平顯著高于對照組(P<0.05);直線相關顯示,尿CTX-Ⅰ水平與股骨頸BMD呈負相關(r=-0.414,P<0.05),與BASDAI、C反應蛋白(CRP)呈正相關(r=0.445,P<0.05;r=0.491,P<0.01).AS患者血清BALP、sOC水平與對照組無統計學意義,且與BMD、BASDAI無明顯相關性.結論 CTX-Ⅰ水平升高提示患者骨吸收增彊、骨密度降低、疾病呈活動性.
목적 통과측정강직성척주염(AS)남성환자혈청골특이성감성린산매(BALP)、혈청골개소(sOC)、뇨Ⅰ형효원C말단태(CTX-Ⅰ)수평,이탐토여질병활동성、골밀도(BMD)적관계.방법 용ELISA방법 측정35명AS환자혈청BALP、sOC、뇨CTX-Ⅰ;용쌍능X선흡수법(DEXA)측정요추정위(AP)L1-L4총체화고골경적BMD,근거Bath강직성척주염질병활동지수(BASDAI)대환자병정진행평분,병여70명건강자대조.결과 AS환자뇨CTX-Ⅰ수평현저고우대조조(P<0.05);직선상관현시,뇨CTX-Ⅰ수평여고골경BMD정부상관(r=-0.414,P<0.05),여BASDAI、C반응단백(CRP)정정상관(r=0.445,P<0.05;r=0.491,P<0.01).AS환자혈청BALP、sOC수평여대조조무통계학의의,차여BMD、BASDAI무명현상관성.결론 CTX-Ⅰ수평승고제시환자골흡수증강、골밀도강저、질병정활동성.
Objective To determine the levels of serum bone-specific alkaline phosphatase(BALP)、serum osteocalcin(sOC),urinary C-terminal telopeptide fragments of type I collagen(CTX-Ⅰ) in men with ankylosing spondylitis (AS) and to investigate their associations with disease activity, bone mineral density(BMD).Methods Serum BALP、sOC,urinary CTX-Ⅰwere determined by enzyme-linked immunosorbent assay in 35 men with AS,areal BMD at the posteroanterior lumbar spine (L1-4) and femoral neck using dual energy X-ray absorptiometry (DEXA). Bath AS Disease Activity Index (BASDAI) were evaluated. Levels of biochemical markers were compared with those of 70 age-matched healthy men.Results Patients with AS had significantly higher mean urinary CTX-I level than control subjects (P< 0.05). Urinary CTX-I levels showed significantly inverse correlations with femoral neck BMD (r = - 0.414, P= 0.030) but not with spinal BMD. There were significantly positive correlations between urinary CTX-I levels and BASDAI (r= 0.445, P= 0.016) as well as between urinary CTX-I and CRP levels (r= 0.491,P= 0.006). Mean serum BALP and osteocalcin levels did not differ between patients and controls and did not show any significant correlations with BMD, BASDAI in men with AS.Conclusion Elevated CTX-I reflects bone resorption、loss of femoral BMD and disease activity.
