CAJ | 학술논문

目的探讨血管紧张素转换酶(ACE)基因多态性对血浆血管紧张素Ⅱ(AngⅡ)水平变化的影响及与新生儿缺氧缺血性损伤(HID)的关系.方法对有缺氧病史新生儿67例及足月健康新生儿32例行ACE基因多态性、AngⅡ等检测.结果实验组ACE基因型构成I/I 29.85%,I/D 49.25%,D/D 20.90%,对照组62.50%,21.88%,15.62%(P＜O.05);实验组I等位基因频率54.48%,D等位基因频率45.52%,对照组73.44%,26.56%(P＜0.05).实验组HID发生率I/I 55.55%,I/D 60.61%,D/D 64.29%(P＜0.05).实验组与对照组L/I纯合子AngⅡ中位数149.52 ng/L与92 ng/L(P＞O.05),非I/I纯合子秩和264.3 ng/L与116.55 ng/L(P＜O.05).实验组Ang ⅡI/I 149.52 ng/L,I/D 280.40 ng/L,D/D 270.15 ng/L,3组间有显著差异(P＜0.05),I/I与D/D比较有显著差异(P＜《0.05),L/D与D/D间无显著差异(P＞0.05).结论携带D等位基因新生儿有易于发生HID的倾向,ACE基因多态性可能是HID发病机制的遗传学基础之一,对存在HID高危因素者行索代及(或)胎儿ACE基因检查可能有助于HID高危筛选并籍此进行预防或早期干预.和264.3 ng/L与116.55 ng/L(P＜O.05).实验组Ang ⅡI/I 149.52 ng/L,I/D 280.40 ng/L,D/D 270.15 ng/L,3组间有显著差异(P＜0.05),I/I与D/D比较有显著差异(P＜《0.05),L/D与D/D问无显著差异(P＞0.05).结论携带D等位基因生儿有易于发生HID的倾向,ACE基因多态性可能是HID发病机制的遗传学基础之一,对存在HID高危因素者行索代及(或)胎儿ACE基因检查可能有助于HID高危筛选并籍此进行预防或早期干
목적 탐토혈관긴장소전환매(ACE)기인다태성대혈장혈관긴장소Ⅱ(AngⅡ)수평변화적영향급여신생인결양결혈성손상(HID)적관계.방법 대유결양병사신생인67례급족월건강신생인32례행ACE기인다태성、AngⅡ등검측.결과 실험조ACE기인형구성I/I 29.85%,I/D 49.25%,D/D 20.90%,대조조62.50%,21.88%,15.62%(P＜O.05);실험조I등위기인빈솔54.48%,D등위기인빈솔45.52%,대조조73.44%,26.56%(P＜0.05).실험조HID발생솔I/I 55.55%,I/D 60.61%,D/D 64.29%(P＜0.05).실험조여대조조L/I순합자AngⅡ중위수149.52 ng/L여92 ng/L(P＞O.05),비I/I순합자질화264.3 ng/L여116.55 ng/L(P＜O.05).실험조Ang ⅡI/I 149.52 ng/L,I/D 280.40 ng/L,D/D 270.15 ng/L,3조간유현저차이(P＜0.05),I/I여D/D비교유현저차이(P＜《0.05),L/D여D/D간무현저차이(P＞0.05).결론 휴대D등위기인신생인유역우발생HID적경향,ACE기인다태성가능시HID발병궤제적유전학기출지일,대존재HID고위인소자행색대급(혹)태인ACE기인검사가능유조우HID고위사선병적차진행예방혹조기간예.화264.3 ng/L여116.55 ng/L(P＜O.05).실험조Ang ⅡI/I 149.52 ng/L,I/D 280.40 ng/L,D/D 270.15 ng/L,3조간유현저차이(P＜0.05),I/I여D/D비교유현저차이(P＜《0.05),L/D여D/D문무현저차이(P＞0.05).결론 휴대D등위기인생인유역우발생HID적경향,ACE기인다태성가능시HID발병궤제적유전학기출지일,대존재HID고위인소자행색대급(혹)태인ACE기인검사가능유조우HID고위사선병적차진행예방혹조기간