中国现代医学杂志
中國現代醫學雜誌
중국현대의학잡지
CHINA JOURNAL OF MODERN MEDICINE
2006年
16期
2401-2404,2409
,共5页
骨质疏松症%骨钙素%尿吡啶啉/肌酐
骨質疏鬆癥%骨鈣素%尿吡啶啉/肌酐
골질소송증%골개소%뇨필정람/기항
osteoporosis%bone gla protein%urinary pyridinoline
目的 了解中老年人骨代谢生化指标随年龄变化的特点,分析骨代谢生化指标在临床应用中的价值.方法 测定410例中老年患者腰椎正位骨密度,同时检测所有患者空腹血清骨钙素、血清碱性磷酸酶及晨尿吡啶啉,尿吡啶啉用肌酐校正.按年龄段和不同骨密度组对男性和女性的骨代谢生化指标值分别进行统计分析.结果 按年龄分析,中老年男性骨钙素随年龄增长下降,尿吡啶啉/肌酐随年龄增长上升,中老年女性骨钙素和尿吡啶啉/肌酐在50～69岁时明显升高.70岁以后又趋于下降,并与同年龄的老年男性的骨钙素、尿吡啶啉/肌酐值相近.而血清碱性磷酸酶不论男性或女性均在正常范围,各年龄段差异无显著性.按骨密度分析,中老年男性骨质疏松组和骨量减低组的骨钙素低于正常组,而尿吡啶啉/肌酐高于正常组,中老年女性骨质疏松组和骨量减低组的骨钙素和尿吡啶啉/肌酐均明显高于正常组.而同性别骨质疏松组和骨量减低组的骨钙素和尿吡啶啉/肌酐值差异无显著性.各骨密度组的血清碱性磷酸酶差异无显著性.结论 血清骨钙素、尿吡啶啉/肌酐分别是反映骨形成和骨吸收特异性和敏感性较高的指标,有助于原发性骨质疏松症的早期诊断.
目的 瞭解中老年人骨代謝生化指標隨年齡變化的特點,分析骨代謝生化指標在臨床應用中的價值.方法 測定410例中老年患者腰椎正位骨密度,同時檢測所有患者空腹血清骨鈣素、血清堿性燐痠酶及晨尿吡啶啉,尿吡啶啉用肌酐校正.按年齡段和不同骨密度組對男性和女性的骨代謝生化指標值分彆進行統計分析.結果 按年齡分析,中老年男性骨鈣素隨年齡增長下降,尿吡啶啉/肌酐隨年齡增長上升,中老年女性骨鈣素和尿吡啶啉/肌酐在50～69歲時明顯升高.70歲以後又趨于下降,併與同年齡的老年男性的骨鈣素、尿吡啶啉/肌酐值相近.而血清堿性燐痠酶不論男性或女性均在正常範圍,各年齡段差異無顯著性.按骨密度分析,中老年男性骨質疏鬆組和骨量減低組的骨鈣素低于正常組,而尿吡啶啉/肌酐高于正常組,中老年女性骨質疏鬆組和骨量減低組的骨鈣素和尿吡啶啉/肌酐均明顯高于正常組.而同性彆骨質疏鬆組和骨量減低組的骨鈣素和尿吡啶啉/肌酐值差異無顯著性.各骨密度組的血清堿性燐痠酶差異無顯著性.結論 血清骨鈣素、尿吡啶啉/肌酐分彆是反映骨形成和骨吸收特異性和敏感性較高的指標,有助于原髮性骨質疏鬆癥的早期診斷.
목적 료해중노년인골대사생화지표수년령변화적특점,분석골대사생화지표재림상응용중적개치.방법 측정410례중노년환자요추정위골밀도,동시검측소유환자공복혈청골개소、혈청감성린산매급신뇨필정람,뇨필정람용기항교정.안년령단화불동골밀도조대남성화녀성적골대사생화지표치분별진행통계분석.결과 안년령분석,중노년남성골개소수년령증장하강,뇨필정람/기항수년령증장상승,중노년녀성골개소화뇨필정람/기항재50～69세시명현승고.70세이후우추우하강,병여동년령적노년남성적골개소、뇨필정람/기항치상근.이혈청감성린산매불론남성혹녀성균재정상범위,각년령단차이무현저성.안골밀도분석,중노년남성골질소송조화골량감저조적골개소저우정상조,이뇨필정람/기항고우정상조,중노년녀성골질소송조화골량감저조적골개소화뇨필정람/기항균명현고우정상조.이동성별골질소송조화골량감저조적골개소화뇨필정람/기항치차이무현저성.각골밀도조적혈청감성린산매차이무현저성.결론 혈청골개소、뇨필정람/기항분별시반영골형성화골흡수특이성화민감성교고적지표,유조우원발성골질소송증적조기진단.
[Objective] To discuss the characters of bone metabolic markers of middle-aged and old people along with the change of age and the value in clinical application with bone metabolic markers. [Methods] Bone mineral density (BMD) of anterior-posterior lumbar spines and fasting serum bone gla protein(BGP), serum alkaline phosphatase (ALP) and urinary pyridinoline(PYD) were tested in 410 patients. Then statistic biochemical criterion value was used in each age stage and different BMD groups with man and woman respectively. [Results] Middle-aged and senile men's BGP lowered down and the PYD/Cr rised with growth of age. Middle-aged and senile women's BGP and PYD/Cr significantly rised from 50 years old to 69 years old, but they showed the lowering trend after 70 years old, which approached to BGB and PYD/Cr of the senile men with the same age. Regardless of serum ALP of men or women in the normal range, there was no obvious difference in each age stage. BGP of middle-aged and senile men osteoporosis group and osteopenia group was lower than that of normal group while the PYD/Cr was higher than that of normal group, BGP and PYD/Cr of middle-aged and senile women osteoporosis group and osteopenia group were significantly higher than that of normal group without obvious difference for BGP and PYD/Cr of osteoporosis group and less bone mass group. There was no significant difference with serum ALP in each group.[Conclusions] The serum BGP and PYD/Cr are specific and sensitive markers for giving expression to bone formation and bone resorption, prior to the change of BMD. Therefore, to test serum BGP and PYD/Cr contributes to the early diagnosis of primary osteoporosis.
