遗传学报
遺傳學報
유전학보
ACTA GENETICA SINICA
2007年
1期
1-9
,共9页
林侠%陈晔光%孟安明%冯新华
林俠%陳曄光%孟安明%馮新華
림협%진엽광%맹안명%풍신화
转化生长因子β(TGF-β)%SMADs%去磷酸化
轉化生長因子β(TGF-β)%SMADs%去燐痠化
전화생장인자β(TGF-β)%SMADs%거린산화
transforming growth factor-β (TGF-β)%SMADs%dephosphorylation
在后生动物机体中,转化生长因子β(TGF-β)及相关生长因子可以通过自分泌、旁分泌及内分泌方式影响广泛的生理活动.它们在多种疾病的发病过程中起着重要的作用,尤其是癌症、纤维化疾病、自免疫疾病和心血管系统疾病.TGF-β受体介导的R-SMADs的磷酸化是TGF-β信号转导通路中最重要的步骤,引起从细胞质内SMAD复合体的组装到核内转录调控这样一个细胞内的信号转导.因此,R-SMADs的去磷酸化是TGF-β信号转导终止的一个重要的机制.最近,我们实验室结合功能基因组学、生物化学和发育生物学的方法,鉴定并研究了磷酸酶PPM1在TGF-β信号转导调控中的功能.文章简短地总结了SMADs动态的磷酸化和去磷酸化是如何调控信号转导的强度和持久性以及TGF-β信号转导的生理功能.
在後生動物機體中,轉化生長因子β(TGF-β)及相關生長因子可以通過自分泌、徬分泌及內分泌方式影響廣汎的生理活動.它們在多種疾病的髮病過程中起著重要的作用,尤其是癌癥、纖維化疾病、自免疫疾病和心血管繫統疾病.TGF-β受體介導的R-SMADs的燐痠化是TGF-β信號轉導通路中最重要的步驟,引起從細胞質內SMAD複閤體的組裝到覈內轉錄調控這樣一箇細胞內的信號轉導.因此,R-SMADs的去燐痠化是TGF-β信號轉導終止的一箇重要的機製.最近,我們實驗室結閤功能基因組學、生物化學和髮育生物學的方法,鑒定併研究瞭燐痠酶PPM1在TGF-β信號轉導調控中的功能.文章簡短地總結瞭SMADs動態的燐痠化和去燐痠化是如何調控信號轉導的彊度和持久性以及TGF-β信號轉導的生理功能.
재후생동물궤체중,전화생장인자β(TGF-β)급상관생장인자가이통과자분비、방분비급내분비방식영향엄범적생리활동.타문재다충질병적발병과정중기착중요적작용,우기시암증、섬유화질병、자면역질병화심혈관계통질병.TGF-β수체개도적R-SMADs적린산화시TGF-β신호전도통로중최중요적보취,인기종세포질내SMAD복합체적조장도핵내전록조공저양일개세포내적신호전도.인차,R-SMADs적거린산화시TGF-β신호전도종지적일개중요적궤제.최근,아문실험실결합공능기인조학、생물화학화발육생물학적방법,감정병연구료린산매PPM1재TGF-β신호전도조공중적공능.문장간단지총결료SMADs동태적린산화화거린산화시여하조공신호전도적강도화지구성이급TGF-β신호전도적생리공능.
The transforming growth factor-β (TGF-β) and related growth factors activate a broad range of cellular responses in metazoan organisms via autocrine, paracrine, and endocrine modes.They play key roles in the pathogenesis of many diseases especially cancer, fibrotic diseases, autoimmune diseases and cardiovascular diseases.TGF-β receptor-mediated phosphorylation of R-SMADs represents the most critical step in the TGF-β signaling pathways that triggers a cascade of intracellular events from SMAD complex assembly in the cytoplasm to transcriptional control in the nucleus.Conversely, dephosphorylation of R-SMADs is a key mechanism for terminating TGF-β signaling.Our labs have recently taken an integrated approach combining functional genomics, biochemistry and development biology to describe the isolation and functional characterization of protein phosphatase PPM1A in controlling TGF-β signaling.This article briefly reviews how dynamic phosphorylation and dephosphorylation of SMADs control or fine-tune the signaling strength and duration and ultimately the physiological consequences in TGF-β signaling.