天然产物研究与开发
天然產物研究與開髮
천연산물연구여개발
NATURAL PRODUCT RESEARCH AND DEVELOPMENT
2004年
1期
7-9
,共3页
成俊英%张晓岚%杨扬%申晓云%张崇本
成俊英%張曉嵐%楊颺%申曉雲%張崇本
성준영%장효람%양양%신효운%장숭본
黄芩素%细胞分化%脂肪酸合成酶%肥胖
黃芩素%細胞分化%脂肪痠閤成酶%肥胖
황금소%세포분화%지방산합성매%비반
baicalein%cell differentiation%fatty acid synthase%obesity
目的研究黄芩素对3T3-L1小鼠前脂肪细胞分化及对脂肪酸合成酶活性的影响.方法油红O染色法测定细胞分化速度;分光光度法测定脂肪酸合成酶活性.结果黄芩素对3T3-L1小鼠前脂肪细胞向脂肪细胞分化以及对脂肪酸合成酶活性有抑制作用.结论黄芩素通过阻断脂肪合成而抑制小鼠前脂肪细胞分化;黄芩素具有开发成减肥药物的潜力.
目的研究黃芩素對3T3-L1小鼠前脂肪細胞分化及對脂肪痠閤成酶活性的影響.方法油紅O染色法測定細胞分化速度;分光光度法測定脂肪痠閤成酶活性.結果黃芩素對3T3-L1小鼠前脂肪細胞嚮脂肪細胞分化以及對脂肪痠閤成酶活性有抑製作用.結論黃芩素通過阻斷脂肪閤成而抑製小鼠前脂肪細胞分化;黃芩素具有開髮成減肥藥物的潛力.
목적연구황금소대3T3-L1소서전지방세포분화급대지방산합성매활성적영향.방법유홍O염색법측정세포분화속도;분광광도법측정지방산합성매활성.결과황금소대3T3-L1소서전지방세포향지방세포분화이급대지방산합성매활성유억제작용.결론황금소통과조단지방합성이억제소서전지방세포분화;황금소구유개발성감비약물적잠력.
Objective To study the effects of baicalein on differentiation of 3T3-L1 murine preadipocytes into adipocytes and on the activities of fatty acid synthase (FAS). Methods Cell differentiation was determined by Oil Red O staining; FAS activity was determined by spectrophotometry. Results Baicalein has inhibition effects on the differentiation of 3T3-L1 preadipocytes into adipocytes and on FAS activities. Conclusion Baicalein attenuates the differentiation of mouse preadipocytes into adipocytes via blocking lipid synthesis and has the potential to be an anti-obesity drug.
