CONSECUTIVE IMMUNIZATION WITH RECOMBINANT FOWLPOX VIRUS AND PLASMID DNA FOR ENHANCING CELLULAR AND HUMORAL IMMUNITY
  • 万方数据
    中国癌症研究(英文版) 중국암증연구(영문판)
    CHINESE JOURNAL OF CANCER RESEARCH
    2001年 4期 247-250 ,共4页

    罗坤%金宁一%郭志儒%秦云龙%郭炎%方厚华%安汝国%殷震

    라곤%금저일%곽지유%진운룡%곽염%방후화%안여국%은진



    Recombinant fowlpox virus%Nucleic acid vaccine plasmid%Consecutive immunization


    To investigate the influence of consecutive immunization on cellular and humoral immunity in mice. Methods: We evaluated a consecutive immunization strategy of priming with recombinant fowlpox virus vUTALG and boosting with plasmid DNA pcDNAG encoding HIV-1 capsid protein Gag. Results: In immunized mice, the number of CD4+ T cells from splenic lymphocytes increased significantly and the proliferation response of splenocytes to ConA and LPS elevated markedly and HIV-1-specific antibody response could be induced. Conclusion: Consecutive immunization could increase cellular and humoral immunity responses in mice.
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