CAJ | 학술논문

目的观察外源性还原型谷胱甘肽对尿毒症贫血的治疗效果。方法将42例尿毒症贫血患者随机分为两组。两组患者均给予重组人红细胞生成素(r-HuEPO)3000U，每周两次皮下注射，疗程12周。治疗组患者同时静脉给予外源性还原型谷胱甘肽(GSH)1200mg，每周两次，疗程12周。于治疗前和治疗后抽静脉血测定血红蛋白（Hb），红细胞(RBC)和红细胞压积(HCT)水平。结果 r-HuEPO治疗后两组患者HB，RBC和HCT水平均显著上升（P<0.01）。GSH治疗组Hb ，RBC和HCT水平与对照组比较上升明显（P<0.05），治疗组Hb,RBC和HCT的上升幅度高于对照组（P<0.05）。结论外源性还原型谷胱甘肽能显著提高r-HuEPO治疗肾性贫血的疗效，GSH可能是治疗尿毒症贫血的有效药物。
목적관찰외원성환원형곡광감태대뇨독증빈혈적치료효과。방법장42례뇨독증빈혈환자수궤분위량조。량조환자균급여중조인홍세포생성소(r-HuEPO)3000U，매주량차피하주사，료정12주。치료조환자동시정맥급여외원성환원형곡광감태(GSH)1200mg，매주량차，료정12주。우치료전화치료후추정맥혈측정혈홍단백（Hb），홍세포(RBC)화홍세포압적(HCT)수평。결과 r-HuEPO치료후량조환자HB，RBC화HCT수평균현저상승（P<0.01）。GSH치료조Hb ，RBC화HCT수평여대조조비교상승명현（P<0.05），치료조Hb,RBC화HCT적상승폭도고우대조조（P<0.05）。결론외원성환원형곡광감태능현저제고r-HuEPO치료신성빈혈적료효，GSH가능시치료뇨독증빈혈적유효약물。
Objective　To verify the therapeutical effect of exogenous reduced glutathione(GSH) on the patients with uremic anemia. Methods　 Forty two patients with uremic anemia were randomly divided into treatment group and control group. All patients received subcutaneously recombinant human erythropoietin (r-HuEPO) at the dose of 3000U twice a week for 12 weeks. Each of the patients in the treatment group was given intravenously reduced glutathione at the dose of 1200mg twice a week for 12 weeks. The measurements of hemoglobin, red blood cells and hematocrit were performed. Results　After administration of r-HuEPO, the levels of hemoglobin, red blood cells and hematocrit were significantly elevated in both treatment and control groups (P<0.01). The levels of hemoglobin, red blood cells and hematocrit in treatment group were elevated much more obviously, compared with those in control group (P<0.05). Conclusion　 These findings seem to indicate that exogenous GSH could enhance the effect of r-HuEPO on uremic anemia,and therefore it might represent a useful drug in the treatment and management of uremic anemia.