CAJ | 학술논문

目的：观察氧化苦参碱(OMT)对豚鼠心室肌细胞钠电流的影响。方法:采用全细胞膜片钳技术。结果:OMT 0.1、0.3和1 mmol/L对钠电流均呈现不同程度的抑制作用，且呈现剂量依赖性。结论:OMT对钠通道的阻滞作用可能是其抗心律失常的作用机制之一。
목적：관찰양화고삼감(OMT)대돈서심실기세포납전류적영향。방법:채용전세포막편겸기술。결과:OMT 0.1、0.3화1 mmol/L대납전류균정현불동정도적억제작용，차정현제량의뢰성。결론:OMT대납통도적조체작용가능시기항심률실상적작용궤제지일。
Objective:Effects of oxymatrine on the sodium current were studied .Methods:The whole cell voltage clamp technique was used in isolated ventricular cells of guinea-pig.Results:Oxymatrine (0.1,0.3 and 1 mmol/L) showed inhibition to the sodium current in dose-dependence.Conclusion:These results indicate that inhibition of oxymatrine to the sodium current may be one of mechanisms of its antiarrhythmic action.