北方工业大学学报
北方工業大學學報
북방공업대학학보
JOURNAL OF NORTH CHINA UNIVERSITY OF TECHNOLOGY
2001年
1期
32-35,44
,共5页
黄酮%抗氧化性%结构%量子化学
黃酮%抗氧化性%結構%量子化學
황동%항양화성%결구%양자화학
用结构化学和量子化学半经验计算方法研究几种典型黄酮类化合物,探讨影响黄酮类化合物抗氧化活性的结构因素.研究结果表明:(1)在分子内形成半醌式自由基时所需能量△HOF较低,其形成的自由基较稳定,从而具有较高的抗氧化活性.(2)电子自旋密度分布的均匀性,是黄酮类抗氧化性较强的重要原因.含邻二酚羟基的黄酮形成的半醌式自由基,电子自旋密度分布比较均匀,而且分子中半醌式基团与邻位酚羟基形成分子内氢键使体系能位降低,因而黄酮类化合物中具有邻二羟基酚的品种比含间二羟基酚的抗氧化活性强.(3)分子中的酚羟基的数目和可以形成氢键的数目与分子的抗氧化活性正相关,是黄酮类化合物具有强抗氧化活性的重要因素.研究表明,通过改变黄酮的羟基取代,使黄酮半醌式自由基的电子自旋密度分布更加均匀,用化学修饰增加黄酮类化合物中的酚羟基数量以及形成分子内氢键的数目是提高黄酮抗氧化活性的途径.
用結構化學和量子化學半經驗計算方法研究幾種典型黃酮類化閤物,探討影響黃酮類化閤物抗氧化活性的結構因素.研究結果錶明:(1)在分子內形成半醌式自由基時所需能量△HOF較低,其形成的自由基較穩定,從而具有較高的抗氧化活性.(2)電子自鏇密度分佈的均勻性,是黃酮類抗氧化性較彊的重要原因.含鄰二酚羥基的黃酮形成的半醌式自由基,電子自鏇密度分佈比較均勻,而且分子中半醌式基糰與鄰位酚羥基形成分子內氫鍵使體繫能位降低,因而黃酮類化閤物中具有鄰二羥基酚的品種比含間二羥基酚的抗氧化活性彊.(3)分子中的酚羥基的數目和可以形成氫鍵的數目與分子的抗氧化活性正相關,是黃酮類化閤物具有彊抗氧化活性的重要因素.研究錶明,通過改變黃酮的羥基取代,使黃酮半醌式自由基的電子自鏇密度分佈更加均勻,用化學脩飾增加黃酮類化閤物中的酚羥基數量以及形成分子內氫鍵的數目是提高黃酮抗氧化活性的途徑.
용결구화학화양자화학반경험계산방법연구궤충전형황동류화합물,탐토영향황동류화합물항양화활성적결구인소.연구결과표명:(1)재분자내형성반곤식자유기시소수능량△HOF교저,기형성적자유기교은정,종이구유교고적항양화활성.(2)전자자선밀도분포적균균성,시황동류항양화성교강적중요원인.함린이분간기적황동형성적반곤식자유기,전자자선밀도분포비교균균,이차분자중반곤식기단여린위분간기형성분자내경건사체계능위강저,인이황동류화합물중구유린이간기분적품충비함간이간기분적항양화활성강.(3)분자중적분간기적수목화가이형성경건적수목여분자적항양화활성정상관,시황동류화합물구유강항양화활성적중요인소.연구표명,통과개변황동적간기취대,사황동반곤식자유기적전자자선밀도분포경가균균,용화학수식증가황동류화합물중적분간기수량이급형성분자내경건적수목시제고황동항양화활성적도경.
The structure-antioxidation relationship of typical flavonoid antioxidants is investigated by means of structural chemistry and the semiempirical calculation method of quantum chemistry. The results suggested that the lesser half-quinone freeradical △HOF make greater antioxidation than the other phenolic hydroxyl in the molecule. The better uniformity of the spin densities distribution of half-quinone freeradical is the essential cause that accounts for the better antioxidation of the flavonoid. Accordingly, the antioxidation of flavonoid containing ortho-substituting hydroxyl is better than that containing meta-substituting hydroxyl,such as the individualization of ortho-dioxy-benzene and meta-dioxy-benzene. The amount of phenol hydroxyl and of intramolecular H-bond in the molecule is in direct relationship with the flavonid antioxidation of the molecule, which contributes to the important factor of the strong antioxidation of flavonoid. While △HOF of half-quinone freeradical of the decorated quercetin discussed is not remarkable minor, and the spin densities is also not noticeable uniform, the antioxidation of the decorated quercetin is better than that of quercetin because the former contains more phenolic hydroxyl and is able to form more intramolecular H-bond. It is shown from the study that the spin densities distribution of half-quinone freeradical is more uniform by changing the locations of hydroxyl substitute, and the increase in the amount of phenol hydroxyl and the amount of intramolecular H-bond in flavonoid molecule by chemical decoration, are the means of improving antioxidation of flavonoid.