中国现代应用药学
中國現代應用藥學
중국현대응용약학
CONTENTS IN BRIEF
2001年
1期
47-48
,共2页
陈继俊%杜劲松%徐明华%韩彬
陳繼俊%杜勁鬆%徐明華%韓彬
진계준%두경송%서명화%한빈
超声波%氨基酸%口 恶唑啉-5-酮%水解
超聲波%氨基痠%口 噁唑啉-5-酮%水解
초성파%안기산%구 악서람-5-동%수해
目的：碱性水解4，4-二取代-2-苯基-2-口恶唑啉-5-酮 1。方法：用超声波促进1水解。结果：1在超声波作用下很快水解，生成N-苯甲酰-2，2-二取代-2-氨基乙酸，没有超声辐照，室温水解需搅拌24h，而有超声辐照，反应仅需15min。结论：超声波能有效促进1的碱性水解。
目的：堿性水解4，4-二取代-2-苯基-2-口噁唑啉-5-酮 1。方法：用超聲波促進1水解。結果：1在超聲波作用下很快水解，生成N-苯甲酰-2，2-二取代-2-氨基乙痠，沒有超聲輻照，室溫水解需攪拌24h，而有超聲輻照，反應僅需15min。結論：超聲波能有效促進1的堿性水解。
목적：감성수해4，4-이취대-2-분기-2-구악서람-5-동 1。방법：용초성파촉진1수해。결과：1재초성파작용하흔쾌수해，생성N-분갑선-2，2-이취대-2-안기을산，몰유초성복조，실온수해수교반24h，이유초성복조，반응부수15min。결론：초성파능유효촉진1적감성수해。
OBJECTIVE:To hydrolyze of 4,4-disubstituted-2-phenyl-2-oxazolin-5-one 1 in base.METHOD:Using ultrasonic irradiation to promote the hydrolysis of 1.RESULTS:1 hydrolyze very quickly with the presence of ultrasonic irradiation and N-benzoyl-α,α-disubstituted glycines were obtained. In room temperature the reaction was completed within 15 min while it had to stir for 24 h without ultrasonic irradiation.CONCLUSION:Ultrasonic irradiation promotes hydrolysis of 1 in base effectively.
