中国媒介生物学及控制杂志
中國媒介生物學及控製雜誌
중국매개생물학급공제잡지
CHINESE JOURNAL OF VECTOR BIOLOGY AND CONTROL
2001年
1期
56-57
,共2页
张稷博%关玉辉%邢丽%王树诚
張稷博%關玉輝%邢麗%王樹誠
장직박%관옥휘%형려%왕수성
β-CD%避蚊胺%白纹伊蚊%毒性%驱避效果
β-CD%避蚊胺%白紋伊蚊%毒性%驅避效果
β-CD%피문알%백문이문%독성%구피효과
目的：采用包结 化合物制作技术，试制缓释驱避剂。方法：用饱和水溶液法制作避 蚊胺包结化合物；按GB 7919-87进行动物急性毒性试验；按GB/T 17322.10-1998进行人体驱 蚊试验。结果:避蚊胺包结化合物对大白鼠急性经口LD50＞ 5 000mg/kg，急性经皮LD50＞3 000mg/kg,对家兔的皮肤和眼睛 无刺激; 20%避蚊胺包结化合物对人体有效保护时间(6.2±0.45)h。结论：避蚊胺包结化合物无急性毒副作用,对光、热的稳定性增强，缓释作用明显。
目的：採用包結 化閤物製作技術，試製緩釋驅避劑。方法：用飽和水溶液法製作避 蚊胺包結化閤物；按GB 7919-87進行動物急性毒性試驗；按GB/T 17322.10-1998進行人體驅 蚊試驗。結果:避蚊胺包結化閤物對大白鼠急性經口LD50＞ 5 000mg/kg，急性經皮LD50＞3 000mg/kg,對傢兔的皮膚和眼睛 無刺激; 20%避蚊胺包結化閤物對人體有效保護時間(6.2±0.45)h。結論：避蚊胺包結化閤物無急性毒副作用,對光、熱的穩定性增彊，緩釋作用明顯。
목적：채용포결 화합물제작기술，시제완석구피제。방법：용포화수용액법제작피 문알포결화합물；안GB 7919-87진행동물급성독성시험；안GB/T 17322.10-1998진행인체구 문시험。결과:피문알포결화합물대대백서급성경구LD50＞ 5 000mg/kg，급성경피LD50＞3 000mg/kg,대가토적피부화안정 무자격; 20%피문알포결화합물대인체유효보호시간(6.2±0.45)h。결론：피문알포결화합물무급성독부작용,대광、열적은정성증강，완석작용명현。
Objective:Trial-produce slow relesase repell ent with inclusion compound technology. Methods: The deet inclusion compound was made in method of saturated solution. Its toxicity was te sted by using method of GB7919-87. Repelling effect of human body was tested b y testing methed of GB/T17322.10-1998. Result:Its oral and dermal LD50 were over 5 000mg/kg and 3 000mg/kg respectively in rats,efficacious time was 6.2±0.54 for human body,it has no dermal and eye irritancy on rabbits. Conclusion: The deet inclusion compound has almost no toxicity for human boday, it was very steady on light and heat, the active in gredient were slow relesase.
