CAJ | 학술논문

目的：探讨聚合酶链反应(PCR)对隐匿性鼻咽癌的诊断意义。方法：采用PCR检测58例颈部肿块的细针抽吸标本中的EB病毒(EBV)。结果：35例颈中、上淋巴结转移癌28例EBV阳性，3例淋巴瘤阴性，4例锁骨上淋巴结转移癌阴性；16例淋巴结炎性病变1例为弱阳性，15例均为阴性；该法诊断鼻咽癌的灵敏度为89．3％，特异性为86．7％。结论：用PCR检测颈部转移癌中的EBV-DNA，对隐匿性鼻咽癌的诊断具有一定的临床意义。
목적：탐토취합매련반응(PCR)대은닉성비인암적진단의의。방법：채용PCR검측58례경부종괴적세침추흡표본중적EB병독(EBV)。결과：35례경중、상림파결전이암28례EBV양성，3례림파류음성，4례쇄골상림파결전이암음성；16례림파결염성병변1례위약양성，15례균위음성；해법진단비인암적령민도위89．3％，특이성위86．7％。결론：용PCR검측경부전이암중적EBV-DNA，대은닉성비인암적진단구유일정적림상의의。
Objective:For the diagnosis of occult nasophargngeal carcinoma. Method:Epstein-Barr virus in 58 fine needle aspirations from cervical metastatic lymphnodes were detected with polymerase chain reaction. Result: The positive reaction was found in 28/35 metastatic carcinoma samples from middle or upside neck. Negative reaction was found in 3 lymphomas,4 metastatic carcinomas in clavicular superior lymphnodes and 15/ 16 inflammatory diseases of cervical lymphnodes. The sensibility of this method for the diagnosis of nasopharyngeal carcinoma was 89.3%. The specificity was 86.7%. Conclusion: The detection of Epstain-Barr virus in metastatic carcinoma from cervical lymphnodes had some clinical values for the diagnosis of occult nasopharyngeal carcinoma.