CAJ | 학술논문

用钙拮抗剂山莨菪碱对感染抗氯喹伯氏疟原虫小鼠进行辅助治疗，高、中、低三个剂量均可明显抑制原虫生长，使小鼠存活时间延长，但剂量为5mg/kg·d或40mg/kg·d时辅助治疗作用明显低于剂量为20mg/kg·d时(此剂量时实验组d4的平均原虫率为46．41‰，对照组67．76‰， 0．005；实验组小鼠死亡时间几何均数为13．64±0．99d，对照组为山莨菪碱逆转伯氏疟原虫氯喹抗药性的作用存在一个最适剂量。
용개길항제산랑탕감대감염항록규백씨학원충소서진행보조치료，고、중、저삼개제량균 가명현억제원충생장，사소서존활시간연장，단제량위5mg/kg·d혹40mg/kg·d시보조치료작용명현저 우제량위20mg/kg·d시(차제량시실험조d4적평균원충솔위46．41‰，대조조67．76‰， 0．005；실험조소서사망시간궤하균수위13．64±0．99d，대조조위 산 랑탕감역전백씨학원충록규항약성적작용존재일개최괄제량。
As an auxiliary treatment, anisodamine, a calcium antagonist, was used to treat mice infected by chloroquine resistant Plasmodium berghei. An obvious reverse effect of the drug on chloroquine resistance was observed. The growth of parasitemia in these mice was inhibited obviously by different doses of anisodamine and the mean survival time of these mice was longer than that of the controls (P<0. 05). It was found that the effect of dose at 20 mg/kg. d was higher than that of dose at 5 mg/kg. d or 40 mg/kg. d and the difference was very significant (P<0. 005). It is considered that anisodamine can reverse chloroquine resistant of Plasmodium berghei and has an optimum reversal dose.