CAJ | 학술논문

目的:筛选蛇床子止痒的有效组分,并探讨其作用机制.方法:采用磷酸组胺致豚鼠瘙痒及低分子右旋糖酐致小鼠瘙痒模型,分别观察蛇床子醇提物、水提物及挥发油的止痒作用;通过其对组胺致离体回肠收缩的影响,探讨其作用机制.结果:蛇床子醇提物及挥发油可显著提高磷酸组胺致豚鼠致瘁闲,减少低分子右旋糖酐致小鼠瘙痒次数,缩短瘙痒时间,而水提物止痒作用不明显.醇提物及挥发油均能抑制磷酸组胺致离体回肠的收缩幅度.结论:蛇床子止痒的有效组分为其醇提物及挥发油,其止痒机制与拮抗组胺的释放相关.
목적:사선사상자지양적유효조분,병탐토기작용궤제.방법:채용린산조알치돈서소양급저분자우선당항치소서소양모형,분별관찰사상자순제물、수제물급휘발유적지양작용;통과기대조알치리체회장수축적영향,탐토기작용궤제.결과:사상자순제물급휘발유가현저제고린산조알치돈서치췌한,감소저분자우선당항치소서소양차수,축단소양시간,이수제물지양작용불명현.순제물급휘발유균능억제린산조알치리체회장적수축폭도.결론:사상자지양적유효조분위기순제물급휘발유,기지양궤제여길항조알적석방상관.
Objective: To research the pharmacodynamics and its related mechanism on antipruritic constituents of fructus Cnidii. Methods: By obsering the effeet of ethanol and water extracts, volatile constituents affect histamine acid phosphate or dextranum-40 inducing itching reaction on guinea pigs and mice and the affect histamine acid phosphate inducing shrinkage reaction of ileum in vitio. Results- ethanol extracts, volatile constituents of fructus Cnidii. can obviously improve histamine acid phosphate inducing itch on guinea pig's skin and restrain dextranum-40 leading to pruritic reaction on the mice's skin. Both of them can Conclusion: ethanol extracts, volatile constituents of fructus Cnidii. possesses obviously effect of antipruritic. One of its mechanisms may be related to the actions of antihistamineantipruritic.