国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2012年
4期
369-371
,共3页
星形胶质%癫(癎)%缝隙连接%谷氨酸%离子通道
星形膠質%癲(癎)%縫隙連接%穀氨痠%離子通道
성형효질%전(간)%봉극련접%곡안산%리자통도
Astrocyte%Epilepsy%Gap junction%Glutamate%Ion channel
离子通道改变、神经递质及其受体调控异常、血脑屏障损伤、炎症、氧化应激损伤等均与癫(癎)发作有关.近年来通过对癫(癎)动物模型、癫(癎)患者尸体解剖或手术切除患者癫(癎)病灶的研究表明,星形胶质与癫(癎)的发生发展有一定的关系,但两者之间的因果关系一直没有定论.目前多数抗癫(癎)药物都是针对神经元,对患者的认知和脑功能都有一定的影响.因此,从星形胶质的角度去探讨癫(癎)的发病机制,有助于发现新的干预靶点以开发新型抗癫(癎)药物.
離子通道改變、神經遞質及其受體調控異常、血腦屏障損傷、炎癥、氧化應激損傷等均與癲(癎)髮作有關.近年來通過對癲(癎)動物模型、癲(癎)患者尸體解剖或手術切除患者癲(癎)病竈的研究錶明,星形膠質與癲(癎)的髮生髮展有一定的關繫,但兩者之間的因果關繫一直沒有定論.目前多數抗癲(癎)藥物都是針對神經元,對患者的認知和腦功能都有一定的影響.因此,從星形膠質的角度去探討癲(癎)的髮病機製,有助于髮現新的榦預靶點以開髮新型抗癲(癎)藥物.
리자통도개변、신경체질급기수체조공이상、혈뇌병장손상、염증、양화응격손상등균여전(간)발작유관.근년래통과대전(간)동물모형、전(간)환자시체해부혹수술절제환자전(간)병조적연구표명,성형효질여전(간)적발생발전유일정적관계,단량자지간적인과관계일직몰유정론.목전다수항전(간)약물도시침대신경원,대환자적인지화뇌공능도유일정적영향.인차,종성형효질적각도거탐토전(간)적발병궤제,유조우발현신적간예파점이개발신형항전(간)약물.
Many studies have shown that changes in ion channels,abnormal regulation of neurotransmitters and their receptors,blood-brain barrier damage,inflammation,oxidative stress etc,are all related with seizures.Animal models of epilepsy,focusing on autopsy of patients with epilepsy or pathological changes of epileptic,have found that there is a certain relationship between astrocytes and epilepsy,but the cause has remained unclear.At present,most of antiepilepfic drugs work on the target of neurons,which have certain impact on the patient's congnitive and brain function.Therefore,to investigate the pathogenesis of epilepsy from the perspective of astcytes,it might help to identify new intervention targets for new antiepileptic drugs.
