CAJ | 학술논문

随着分子生物学的不断进步发展,对头颈肿瘤的治疗手段也由传统的手术和放疗向基因领域拓展.小分子干扰RNA(siRNA)技术也成为各类头颈肿瘤中的重要研究方向.siRNA可以达到抑制肿瘤细胞增殖、干扰细胞信号传导、诱导细胞凋亡和逆转肿瘤细胞的多药耐药等作用,有望成为头颈肿瘤综合治疗的有效补充手段.
수착분자생물학적불단진보발전,대두경종류적치료수단야유전통적수술화방료향기인영역탁전.소분자간우RNA(siRNA)기술야성위각류두경종류중적중요연구방향.siRNA가이체도억제종류세포증식、간우세포신호전도、유도세포조망화역전종류세포적다약내약등작용,유망성위두경종류종합치료적유효보충수단.
Because of the development of molecular biology, not only operation and radiotherapy are treatments for the disease ,hut also the gene therapy, siRNA becomes the research target in some kinds of head and neck neoplasms, siRNA can inhibit proliferation,interfere with cell signal transduction,induce apoptosis and reverse the multi-drug resistance. So it may be a promising additional method for combined therapy of tumors.