CAJ | 학술논문

秋水仙碱为一天然产物,自百合科植物秋水仙中提取,其应用于临床历史悠久,具有抗有丝分裂、抗炎症、免疫抑制作用.痛风和家族性地中海热是秋水仙碱的绝对适应证,近年来在临床应用中发现,秋水仙碱治疗某些特定皮肤病,如某些中性粒细胞浸润性皮肤病、银屑病、大疱性皮肤病等有良好的疗效.秋水仙碱低剂量时一般耐受良好,不良反应少,但过量使用时毒副作用较多,因此,临床应用时需注意药物的不良反应及药物间的相互作用,并及时监测相关指标.
추수선감위일천연산물,자백합과식물추수선중제취,기응용우림상역사유구,구유항유사분렬、항염증、면역억제작용.통풍화가족성지중해열시추수선감적절대괄응증,근년래재림상응용중발현,추수선감치료모사특정피부병,여모사중성립세포침윤성피부병、은설병、대포성피부병등유량호적료효.추수선감저제량시일반내수량호,불량반응소,단과량사용시독부작용교다,인차,림상응용시수주의약물적불량반응급약물간적상호작용,병급시감측상관지표.
Colchicine,a toxic natural product and the active principle ot Colchicum autumnale,has been known since antiquity for its medicinal uses.It possesses anti-mitotic,anti-inflammatory and immunosuppressive activities.There are two non-dermatologic absolute indications of colchicine: acute gout crisis and familial Mediterranean fever.Several uncontrolled clinical studies have shown exciting outcomes in the treatment of some dermatologic diseases with colchicines,such as neutrophilic dermatoses,psoriasis,bullous dermatoses,and so on.Low dose of colchicine is well tolerable with less adverse reactions,while large dose of colchicine is associated with considerable toxic and side effects.Hence,attention should be paid to adverse reactions and drug interactions as well as relevant parameters during the clinical application of colchicines.