CAJ | 학술논문

糖尿病是严重威胁人类健康的代谢紊乱性疾病.干细胞具有自我更新和多向分化潜能.来源于成体干细胞和胚胎干细胞的胰岛细胞移植也许是有前途的糖尿病治疗方法.干细胞体外培养时可以自发或诱导分化为胰岛素分泌细胞,部分实验证实移植后的胰岛素分泌细胞可以纠正糖尿病小鼠的高血糖状态,这一研究为糖尿病细胞替代治疗带来希望.
당뇨병시엄중위협인류건강적대사문란성질병.간세포구유자아경신화다향분화잠능.래원우성체간세포화배태간세포적이도세포이식야허시유전도적당뇨병치료방법.간세포체외배양시가이자발혹유도분화위이도소분비세포,부분실험증실이식후적이도소분비세포가이규정당뇨병소서적고혈당상태,저일연구위당뇨병세포체대치료대래희망.
Diabetes mellitus is a metabolic disorder threatening to global public health. Stem cells have capabilities of both self-renewal and muhilineage differentiation. Cell replacement therapy via islet cells derived from adult and embryonic stem cells may be a promising therapeutic option for the treatment of diabe-tes. Stem cells could be spontaneous or induced differentiation into insulin-producing cells in vitro. Subse-quent transplantation of these cells to streptozotocin-induced diabetic mice could correct their glycemia, which brings us the hope for the treatment of diabetes mellitus in future.