CAJ | 학술논문

目的通过观察哮喘急性发作的婴幼儿雾化吸入硫酸沙丁胺醇前后肺功能的变化,客观评价该药对低龄儿童气道阻力的影响.方法将轻中度哮喘急性发作的49名婴幼儿按年龄分为1～3岁幼儿(32例)和<1岁婴儿(17例)两组,予0.5%硫酸沙丁胺醇0.25ml/次,驱动式压缩泵雾化吸入,在治疗前及后30min分别检查其肺功能,做潮气呼吸流速容量环检查,采用到达潮气呼气峰流速时的呼气量/潮气量(%V-PF)、呼出75%潮气量时的呼气流速/潮气呼气蜂流速(25/PF)和潮气呼气中期流速/潮气吸气中期流速(ME/MI)参数反映大小气道阻力情况.结果在幼儿组和婴儿组治疗前肺功能指标%V-PF、25/PF和ME/NI降低,显示大小气道阻力增高,治疗后幼儿组肺功能各指标均有所提高,比较差异有统计学意义(P<0.01);婴儿组治疗前后比较差异无统计学意义(P>0.05).结论对幼儿哮喘急性发作予雾化吸人硫酸沙丁胺醇后能有效地改善肺功能,降低气道阻力,对婴儿治疗的关键是结合有效的抗炎和积极的祛痰.
목적 통과관찰효천급성발작적영유인무화흡입류산사정알순전후폐공능적변화,객관평개해약대저령인동기도조력적영향.방법 장경중도효천급성발작적49명영유인안년령분위1～3세유인(32례)화<1세영인(17례)량조,여0.5%류산사정알순0.25ml/차,구동식압축빙무화흡입,재치료전급후30min분별검사기폐공능,주조기호흡류속용량배검사,채용도체조기호기봉류속시적호기량/조기량(%V-PF)、호출75%조기량시적호기류속/조기호기봉류속(25/PF)화조기호기중기류속/조기흡기중기류속(ME/MI)삼수반영대소기도조력정황.결과 재유인조화영인조치료전폐공능지표%V-PF、25/PF화ME/NI강저,현시대소기도조력증고,치료후유인조폐공능각지표균유소제고,비교차이유통계학의의(P<0.01);영인조치료전후비교차이무통계학의의(P>0.05).결론 대유인효천급성발작여무화흡인류산사정알순후능유효지개선폐공능,강저기도조력,대영인치료적관건시결합유효적항염화적겁적거담.
Objective It is to observe the change of the pulmonary function before and after inhaling the salbutamol by iofants with acute episode of asthma in order to objectively estimate the medicine influence on the air way resistance of the young children.Methods Forty-nine infants with light and rnidrange acute episode of asthma were divided into two groups according to age,32 infants were 1～3 years old and 17 ones were younger than one.0.25 ml atomizing 0.5% salbutamol sulfate was inhaled each time. The ptdmonary function was checked respectively in 30 minutes before and after inhaling. Examine the change of tidal breathing flow volume (TBFV loop), ratio of tidal volume to peak tidal expiratory flow (%V-PF), terminal flows per peak expiratory flow (25/PF),and rate of mid-expiratory to mid-inspiratory (ME/MI) to expose the condition of the air way resistance. Results In the group of young children with one to three years old, the indexes of the pulmonary function were improved after inhaling the medicine, and aresigniticantly compared with which before inhaling (P<0.01) ;the other group shows no significance (P>0.05) after treating. Conclusion Inhaling the atomizing 0.5 % salbutamol sulfate can effectively improve the pulmonary function of the young children with acute episode of asthma and reduce air way resistance,therefore, the key to cure this disease is evacuation of secretion in airway and anti-inflammation for the infants.