国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2011年
2期
155-157
,共3页
卵巢肿瘤%信号传导%药物疗法
卵巢腫瘤%信號傳導%藥物療法
란소종류%신호전도%약물요법
Ovarian neoplasms%Signal transduction%Drug therapy
磷脂酰肌醇3-激酚蛋白激酶B(PI3K/Akt)信号通路上的正调控因子PI3K、Akt在卵巢癌中往往是激活的,而负调控磷酸酶基因张力蛋白同源物基因(PTEN)的功能往往缺失.它们共同调节肿瘤细胞的增殖和凋亡,并与肿瘤的血管形成和侵袭转移也密切相关.因此PI3K/Akt信号通路异常影响患者的预后,同时也为肿瘤的治疗提供了新的靶点.
燐脂酰肌醇3-激酚蛋白激酶B(PI3K/Akt)信號通路上的正調控因子PI3K、Akt在卵巢癌中往往是激活的,而負調控燐痠酶基因張力蛋白同源物基因(PTEN)的功能往往缺失.它們共同調節腫瘤細胞的增殖和凋亡,併與腫瘤的血管形成和侵襲轉移也密切相關.因此PI3K/Akt信號通路異常影響患者的預後,同時也為腫瘤的治療提供瞭新的靶點.
린지선기순3-격분단백격매B(PI3K/Akt)신호통로상적정조공인자PI3K、Akt재란소암중왕왕시격활적,이부조공린산매기인장력단백동원물기인(PTEN)적공능왕왕결실.타문공동조절종류세포적증식화조망,병여종류적혈관형성화침습전이야밀절상관.인차PI3K/Akt신호통로이상영향환자적예후,동시야위종류적치료제공료신적파점.
Positive regulative factors of PI3K/Akt signaling pathways is often activated in ovarian cancer, whereas the function of negative regulator PTEN is often defective. These two kinds of regulators cooperatively regulate tumor cell proliferation and apoptosis in closely association with tumor angiogenesis and invasion and metastasis. It has been suggested that PI3K-Akt pathway is not only related to prognosis of tumor patients but can also be used as novel targets for tumor therapy.