中华临床感染病杂志
中華臨床感染病雜誌
중화림상감염병잡지
CHINESE JOURNAL OF CLINICAL INFECTIOUS DISEASES
2009年
3期
159-161
,共3页
降钙素%骨折%感染
降鈣素%骨摺%感染
강개소%골절%감염
Caleitonin%Fractures,bone%Infections
目的 探讨降钙素原(PCT)、C反应蛋白(CRP)和WBC对骨折患者术后感染的预测价值.方法 回顾性分析49例开放性骨折患者的资料,根据术后感染情况分为术后感染组(24例)和无感染组(25例),分别在第1、4、7和第10天检测患者血液中的PCT、CRP和WBC值,并与健康对照组进行比较.应用受试者工作特征(ROC)的曲线下面积分析各指标对术后感染的诊断价值.结果 感染组和无感染组术后第1天PCT、CRP和WBC与健康对照组比较,差异有统计学意义(F值分别为19.84、57.71和35.44,P值均＜0.01).术后第4、7和第10天,感染组的PCT、CRP和WBC值均高于无感染组,且差异有统计学意义(tPCT值分别为7.31、7.74和4.59,tCRP值分别为2.23、5.75和8.01,tWBC值分别为2.34、2.51和4.07,P值均＜0.05).ROC曲线分析表明,PCT对开放性骨折术后感染诊断的特异性和敏感性均高于CRP和WBC.结论 骨折术后并发感染可引起PCT、CRP和WBC的增高,PCT检测的敏感性和特异性较高,对骨折术后感染的早期诊断更具临床价值.
目的 探討降鈣素原(PCT)、C反應蛋白(CRP)和WBC對骨摺患者術後感染的預測價值.方法 迴顧性分析49例開放性骨摺患者的資料,根據術後感染情況分為術後感染組(24例)和無感染組(25例),分彆在第1、4、7和第10天檢測患者血液中的PCT、CRP和WBC值,併與健康對照組進行比較.應用受試者工作特徵(ROC)的麯線下麵積分析各指標對術後感染的診斷價值.結果 感染組和無感染組術後第1天PCT、CRP和WBC與健康對照組比較,差異有統計學意義(F值分彆為19.84、57.71和35.44,P值均＜0.01).術後第4、7和第10天,感染組的PCT、CRP和WBC值均高于無感染組,且差異有統計學意義(tPCT值分彆為7.31、7.74和4.59,tCRP值分彆為2.23、5.75和8.01,tWBC值分彆為2.34、2.51和4.07,P值均＜0.05).ROC麯線分析錶明,PCT對開放性骨摺術後感染診斷的特異性和敏感性均高于CRP和WBC.結論 骨摺術後併髮感染可引起PCT、CRP和WBC的增高,PCT檢測的敏感性和特異性較高,對骨摺術後感染的早期診斷更具臨床價值.
목적 탐토강개소원(PCT)、C반응단백(CRP)화WBC대골절환자술후감염적예측개치.방법 회고성분석49례개방성골절환자적자료,근거술후감염정황분위술후감염조(24례)화무감염조(25례),분별재제1、4、7화제10천검측환자혈액중적PCT、CRP화WBC치,병여건강대조조진행비교.응용수시자공작특정(ROC)적곡선하면적분석각지표대술후감염적진단개치.결과 감염조화무감염조술후제1천PCT、CRP화WBC여건강대조조비교,차이유통계학의의(F치분별위19.84、57.71화35.44,P치균＜0.01).술후제4、7화제10천,감염조적PCT、CRP화WBC치균고우무감염조,차차이유통계학의의(tPCT치분별위7.31、7.74화4.59,tCRP치분별위2.23、5.75화8.01,tWBC치분별위2.34、2.51화4.07,P치균＜0.05).ROC곡선분석표명,PCT대개방성골절술후감염진단적특이성화민감성균고우CRP화WBC.결론 골절술후병발감염가인기PCT、CRP화WBC적증고,PCT검측적민감성화특이성교고,대골절술후감염적조기진단경구림상개치.
Objective To investigate the significance of procalcitonin(PCT),C-reactive protein (CRP)and WBC counts in predicting the postoperative jnfections in patients with bone fractures.Methods Clinical data of 49 patients with open fractures were retrospectively analyzed,and the patients were grouped into the infeeted(n=24)and non.infected(n=25).PCT,CRP and WBC values were detected 1,4,7and 10 days after the operations,and the results were compared with those taken from the healthy controls.Areas under the receiver operating characteristic(ROC)curves were used to determine the value in predicting postoperative infections.Results PCT,CRP and WBC values in the infected group and the noninfected group were higher than those in health controls(F=19.84,57.71 and 35.44,P＜0.01).PCT,CRP and WBC values in the infected group were higher than those in the non-infected group 4.7 and 10 days after the operations(tPCT=7.31,7.74 and 4.59;tCRP=2.23,5.75 and 8.01;tWBC=2.34,2.51 and 4.07,P＜0.05).ROC curves suggested that PCT value was more sensitive and had higher specificity than CRP and WBC values in the diagnosis of postoperative infections.Conclusions PCT,CRP and WBC values arise in bone fracture patients with postoperative infections.Detection of PCT has higher sensitivity and specificity.which can be used in early diagnosis of postoperative infections.
