CAJ | 학술논문

目的探讨肺癌合并血嗜酸性粒细胞增多的临床特点及意义.方法结合我院收治的1例肺癌合并嗜酸性粒细胞增多的临床资料及国外文献报道的实体肿瘤合并嗜酸性粒细胞增多的病例报道进行综合分析.结果患者男,80岁,表现为右侧胸痛,呈持续性钝痛,胸部CT示右肺上叶后段厚壁空洞,伴邻近骨质破坏,右肺动脉及右主支气管受侵,右侧少量胸腔积液.血嗜酸性粒细胞增多,比例为0.169,绝对值2.15×109/L,痰及支气管灌洗液中嗜酸性粒细胞比例也明显增高.CT引导下穿刺活检显示为鳞癌.患者发现合并嗜酸性粒细胞时,肺癌已有转移,预后差,与文献报道一致.结论肺癌等恶性肿瘤通过分泌嗜酸性粒细胞克隆刺激因子引发血嗜酸性粒细胞增多,为较少见的副癌综合征,提示肿瘤已有转移,预后差.
목적 탐토폐암합병혈기산성립세포증다적림상특점급의의.방법 결합아원수치적1례폐암합병기산성립세포증다적림상자료급국외문헌보도적실체종류합병기산성립세포증다적병례보도진행종합분석.결과 환자남,80세,표현위우측흉통,정지속성둔통,흉부CT시우폐상협후단후벽공동,반린근골질파배,우폐동맥급우주지기관수침,우측소량흉강적액.혈기산성립세포증다,비례위0.169,절대치2.15×109/L,담급지기관관세액중기산성립세포비례야명현증고.CT인도하천자활검현시위린암.환자발현합병기산성립세포시,폐암이유전이,예후차,여문헌보도일치.결론 폐암등악성종류통과분비기산성립세포극륭자격인자인발혈기산성립세포증다,위교소견적부암종합정,제시종류이유전이,예후차.
Objective To study the clinical characteristics and significance of blood eosinophilia in lung cancer.Methods A case of lung cancer with eosinophilia in the peripheral blood was analyzed,and the related literature was reviewed.Results A 80 year-old male patient presented with chest pain was admitted to this hospital.Chest CT scan showed a cavity in the right upper lung.Peripheral blood leukocyte count was 2.15 x 109/L,of which 16.9% was mature eosinophils.Histological examination of the biopsy specimens obtained under CT guidance confirmed the diagnosis of lung squamous cell carcinoma.There was also evidence of metastasis to the bones.Conclusions Paraneoplastic eosinophilia is uncommon in solid malignancies and indicative of tumor dissemination with generally poor prognosis.