CAJ | 학술논문

目的探讨幽门螺杆菌(Hp)感染对脑梗死患者血脂和超敏C反应蛋白(hs-CRP)的影响,并探讨其发病机制.方法对确诊的79例脑梗死患者且近期无炎性反应性疾病,采用呼气试验来检测是否感染Hp,根据呼气试验将脑梗死患者分为感染阴性组15例、轻度感染组29例和重度感染组35例,后两者合称为感染阳性组,同时测定hs-CRP和血脂水平.结果与感染阴性组患者比较,感染阳性组患者总胆固醇、低密度脂蛋白及hs-CRP水平明显升高(P＜0.05);重度感染组hs-CRP 水平为(10.21±4.98)mg/L,明显高于轻度感染组的(5.81±4.21)mg/L(P=0.001).结论 Hp感染可能通过影响脂质代谢加重血管壁的炎性反应,导致更多的缺血性卒中事件发生,并随着感染程度加重,风险性亦相应增加.
목적 탐토유문라간균(Hp)감염대뇌경사환자혈지화초민C반응단백(hs-CRP)적영향,병탐토기발병궤제.방법 대학진적79례뇌경사환자차근기무염성반응성질병,채용호기시험래검측시부감염Hp,근거호기시험장뇌경사환자분위감염음성조15례、경도감염조29례화중도감염조35례,후량자합칭위감염양성조,동시측정hs-CRP화혈지수평.결과 여감염음성조환자비교,감염양성조환자총담고순、저밀도지단백급hs-CRP수평명현승고(P＜0.05);중도감염조hs-CRP 수평위(10.21±4.98)mg/L,명현고우경도감염조적(5.81±4.21)mg/L(P=0.001).결론 Hp감염가능통과영향지질대사가중혈관벽적염성반응,도치경다적결혈성졸중사건발생,병수착감염정도가중,풍험성역상응증가.
Objective To investigate the effect of Helicobacter pylori (Hp) infection on plasma lpid and high sensitive C reactive protein (hs-CRP) levels in patients with cerebral infarction, and explore the pathogenesy. Methods Seventy-nine cerebral infarction patients without nearly inflammatory reaction disease were recruited. Hp was detected by breath test,the patients were divided into infection-negative group (15 cases), light infection group (29 cases) and severe infection group(35 cases) according to the results,the last two groups were as infection-positive group. The plasma lipid and hs-CRP levels were exanined.Results Compared with infection-negative group,the total cholesterol,low density lipoprotein,hs-CRP levels increased obviously in infecton-positive group (P ＜ 0.05). The level of hs-CRP in severe infection group was higher than that in light infection group [(10.21 ±4.98) mg/L vs. (5.81 ±4.21) mg/L](P=0.001 ). Conclusions Hp infection may increase vascular inflammatory reaction through lipid metabolic disturbance. The cerebral infarction with higher Hp infection, and with the degree of infection increased, the risk is also increased accordingly.