中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2011年
7期
599-601
,共3页
舍曲林%抑郁症%血清细胞因子%c-反应蛋白
捨麯林%抑鬱癥%血清細胞因子%c-反應蛋白
사곡림%억욱증%혈청세포인자%c-반응단백
Sertraline%Depression%Serum cytokines%c-reactive protein
目的 探讨抑郁症与血清细胞因子(CK)及C-反应蛋白的关系,了解舍曲林对血清白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、肿瘤坏死因子-a(TNF-α)和C反应蛋白(CRP)水平的影响.方法 采用酶联免疫吸附法(ELISA)检测50例抑郁症患者(研究组)舍曲林治疗前后及25名正常人血清IL-2,IL-6,TNF-α水平,采用散射比浊法测定CRP水平,采用汉密尔顿抑郁量表(HAMD)评估抑郁症患者治疗前后的抑郁症状.结果 研究组患者治疗前血清IL-2,IL-6,TNF-α和CRP水平[分别为(41.4±15.7)pg/ml,(63.4±17.2)pg/ml,(81.4±19.3)pg/ml,(8.2±2.9)mg/L],高于正常对照组[分别为(13.2±4.6)pg/ml,(21.3±7.7)pg/ml,(35.1±7.8)pg/ml,(2.9±0.5)mg/L],差异具有显著性(P<0.01);治疗后IL-2,IL-6,TNF-α和CRP水平[分别为(20.1±9.1)pg/ml,(38.5±11.6)pg/ml,(49.5±12.6)pg/ml,(4.2±1.6)ms/L],低于治疗前,差异具有显著性(P<0.01).研究组血清IL-2,IL-6、TNF-α与抑郁症患者目前年龄、HAMD总分呈显著正相关(P<0.05,P<0.01),IL-2,IL-6、TNF-α变化率与HAMD减分率呈显著止相关(P<0.05,P<0.01).结论 抑郁症患者存在血清IL-2,IL-6,TNF-α,CRP水平的升高,舍曲林在改善抑郁症状的同时能降低抑郁症患者血清IL-2,IL-6,TNF-α,CRP水平.
目的 探討抑鬱癥與血清細胞因子(CK)及C-反應蛋白的關繫,瞭解捨麯林對血清白細胞介素-2(IL-2)、白細胞介素-6(IL-6)、腫瘤壞死因子-a(TNF-α)和C反應蛋白(CRP)水平的影響.方法 採用酶聯免疫吸附法(ELISA)檢測50例抑鬱癥患者(研究組)捨麯林治療前後及25名正常人血清IL-2,IL-6,TNF-α水平,採用散射比濁法測定CRP水平,採用漢密爾頓抑鬱量錶(HAMD)評估抑鬱癥患者治療前後的抑鬱癥狀.結果 研究組患者治療前血清IL-2,IL-6,TNF-α和CRP水平[分彆為(41.4±15.7)pg/ml,(63.4±17.2)pg/ml,(81.4±19.3)pg/ml,(8.2±2.9)mg/L],高于正常對照組[分彆為(13.2±4.6)pg/ml,(21.3±7.7)pg/ml,(35.1±7.8)pg/ml,(2.9±0.5)mg/L],差異具有顯著性(P<0.01);治療後IL-2,IL-6,TNF-α和CRP水平[分彆為(20.1±9.1)pg/ml,(38.5±11.6)pg/ml,(49.5±12.6)pg/ml,(4.2±1.6)ms/L],低于治療前,差異具有顯著性(P<0.01).研究組血清IL-2,IL-6、TNF-α與抑鬱癥患者目前年齡、HAMD總分呈顯著正相關(P<0.05,P<0.01),IL-2,IL-6、TNF-α變化率與HAMD減分率呈顯著止相關(P<0.05,P<0.01).結論 抑鬱癥患者存在血清IL-2,IL-6,TNF-α,CRP水平的升高,捨麯林在改善抑鬱癥狀的同時能降低抑鬱癥患者血清IL-2,IL-6,TNF-α,CRP水平.
목적 탐토억욱증여혈청세포인자(CK)급C-반응단백적관계,료해사곡림대혈청백세포개소-2(IL-2)、백세포개소-6(IL-6)、종류배사인자-a(TNF-α)화C반응단백(CRP)수평적영향.방법 채용매련면역흡부법(ELISA)검측50례억욱증환자(연구조)사곡림치료전후급25명정상인혈청IL-2,IL-6,TNF-α수평,채용산사비탁법측정CRP수평,채용한밀이돈억욱량표(HAMD)평고억욱증환자치료전후적억욱증상.결과 연구조환자치료전혈청IL-2,IL-6,TNF-α화CRP수평[분별위(41.4±15.7)pg/ml,(63.4±17.2)pg/ml,(81.4±19.3)pg/ml,(8.2±2.9)mg/L],고우정상대조조[분별위(13.2±4.6)pg/ml,(21.3±7.7)pg/ml,(35.1±7.8)pg/ml,(2.9±0.5)mg/L],차이구유현저성(P<0.01);치료후IL-2,IL-6,TNF-α화CRP수평[분별위(20.1±9.1)pg/ml,(38.5±11.6)pg/ml,(49.5±12.6)pg/ml,(4.2±1.6)ms/L],저우치료전,차이구유현저성(P<0.01).연구조혈청IL-2,IL-6、TNF-α여억욱증환자목전년령、HAMD총분정현저정상관(P<0.05,P<0.01),IL-2,IL-6、TNF-α변화솔여HAMD감분솔정현저지상관(P<0.05,P<0.01).결론 억욱증환자존재혈청IL-2,IL-6,TNF-α,CRP수평적승고,사곡림재개선억욱증상적동시능강저억욱증환자혈청IL-2,IL-6,TNF-α,CRP수평.
Objective To investigate the association between serum cytokines and depression and understand the effect of sertraline on serum leveI of interleukin 2(IL-2),interleukin 6(IL-6),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP).Methods A total of 50 depressive patients(study group) and 25 healthy controls(control group)were included in this study.The levels of serum IL-2,IL-6 and TNF-α were measured by enzymatic-linked immunosorbent assay(ELISA)on baseline and after treatment,CRP were measured by scatter rate nephelometry.Depressive patients were assessed by Hamilton depression sere(HAMD)on baseline and after treatment.Results The levels of IL-2(41.4±15.7)pg/ml,IL-6(63.4±17.2)pg/ml,TNF-α(81.4±19.3)pg/ml and CRP(8.2±2.9)mg/L in study group were significantly higher than those in control group(13.2±4.6)pg/ml,(21.3±7.7)ps/ml,(35.1±7.8)ps/ml,(2.9±0.5)mg/L,(P<0.01).Compared with baseline,the levels of serum IL-2(20.1±9.1)ps/ml,IL-6(38.5±11.6)pg/ml,TNF-a(49.5±12.6)pg/ml and CRP(4.2±1.6)mg/L after treatment by sertraline decreased significantly(P<0.01).In study group,there were significant positive correlations between the serum level of IL-2,IL-6,TNF-α and present age,the total score of HAMD(P<0.05,P<0.01).There were significant positive correlations between variation rates of serum IL-2,IL-6,TNF-αand reduction rate of HAMD(P<0.05,P<0.01).Conclusion The serum levels of IL-2,IL-6,TNF-α and CRP increased in patients with depression.Sertraline may affect depressive patients'serum levels of IL-2,IL-6,TNF-αand CRP.
