中华神经科杂志
中華神經科雜誌
중화신경과잡지
Chinese Journal of Neurology
2009年
2期
95-97
,共3页
曾文双%褚晓凡%陶细姣%古美华
曾文雙%褚曉凡%陶細姣%古美華
증문쌍%저효범%도세교%고미화
帕金森病%震颤%肌电描记术
帕金森病%震顫%肌電描記術
파금삼병%진전%기전묘기술
Parkinson disease%Tremor%Electromyography
目的 从帕金森震颤的频率、强度和药物反应的角度探寻帕金森震颤的肌电图特点.方法 选取符合诊断标准的帕金森震颤患者66例,利用十导肌电图仪和标准化震颤分析软件TRAS采集帕金森病患者静止性震颤和姿势性震颤的频率和强度,比较帕金森静止性震颤和姿势性震颤之间频率、强度的差异有无统计学意义,帕金森震颤的频率、强度之间有无线性相关关系以及帕金森震颤患者规则用药前后震颤频率和强度的变化.结果 帕金森静止性震颤较姿势性震颤的频率低,分别为(4.79±0.69)Hz和(5.54±1.18)Hz,差异具有统计学意义(F=33.5,P<0.01),强度分别为0.016～421.700(mg)2和0.062～217.900(mg)2,差异无统计学意义(F=1.917,P>0.05);帕金森震颤的频率和强度之间无线性相关关系(r=0.09,P>0.05);帕金森病患者服药后的震颤强度较服药前明显降低,分别为0.016～421.700(mg)2和0.027～82.200(mg)2,差异具有统计学意义(F=5.179,P<0.05),而服药前后的震颤频率分别为(5.09±0.85)Hz和(5.20±1.08)Hz,差异无统计学意义(F=0.474,P>0.05).结论 帕金森静止性震颤和姿势性震颤可能存在着不同的震颤发生机制,帕金森震颤强度的易变性导致震颤频率与强度之间不具有线性相关性,药物治疗只能缓解帕金森震颤的症状,而对导致帕金森震颤的中枢性振荡器不具有逆转性作用.
目的 從帕金森震顫的頻率、彊度和藥物反應的角度探尋帕金森震顫的肌電圖特點.方法 選取符閤診斷標準的帕金森震顫患者66例,利用十導肌電圖儀和標準化震顫分析軟件TRAS採集帕金森病患者靜止性震顫和姿勢性震顫的頻率和彊度,比較帕金森靜止性震顫和姿勢性震顫之間頻率、彊度的差異有無統計學意義,帕金森震顫的頻率、彊度之間有無線性相關關繫以及帕金森震顫患者規則用藥前後震顫頻率和彊度的變化.結果 帕金森靜止性震顫較姿勢性震顫的頻率低,分彆為(4.79±0.69)Hz和(5.54±1.18)Hz,差異具有統計學意義(F=33.5,P<0.01),彊度分彆為0.016～421.700(mg)2和0.062～217.900(mg)2,差異無統計學意義(F=1.917,P>0.05);帕金森震顫的頻率和彊度之間無線性相關關繫(r=0.09,P>0.05);帕金森病患者服藥後的震顫彊度較服藥前明顯降低,分彆為0.016～421.700(mg)2和0.027～82.200(mg)2,差異具有統計學意義(F=5.179,P<0.05),而服藥前後的震顫頻率分彆為(5.09±0.85)Hz和(5.20±1.08)Hz,差異無統計學意義(F=0.474,P>0.05).結論 帕金森靜止性震顫和姿勢性震顫可能存在著不同的震顫髮生機製,帕金森震顫彊度的易變性導緻震顫頻率與彊度之間不具有線性相關性,藥物治療隻能緩解帕金森震顫的癥狀,而對導緻帕金森震顫的中樞性振盪器不具有逆轉性作用.
목적 종파금삼진전적빈솔、강도화약물반응적각도탐심파금삼진전적기전도특점.방법 선취부합진단표준적파금삼진전환자66례,이용십도기전도의화표준화진전분석연건TRAS채집파금삼병환자정지성진전화자세성진전적빈솔화강도,비교파금삼정지성진전화자세성진전지간빈솔、강도적차이유무통계학의의,파금삼진전적빈솔、강도지간유무선성상관관계이급파금삼진전환자규칙용약전후진전빈솔화강도적변화.결과 파금삼정지성진전교자세성진전적빈솔저,분별위(4.79±0.69)Hz화(5.54±1.18)Hz,차이구유통계학의의(F=33.5,P<0.01),강도분별위0.016～421.700(mg)2화0.062～217.900(mg)2,차이무통계학의의(F=1.917,P>0.05);파금삼진전적빈솔화강도지간무선성상관관계(r=0.09,P>0.05);파금삼병환자복약후적진전강도교복약전명현강저,분별위0.016～421.700(mg)2화0.027～82.200(mg)2,차이구유통계학의의(F=5.179,P<0.05),이복약전후적진전빈솔분별위(5.09±0.85)Hz화(5.20±1.08)Hz,차이무통계학의의(F=0.474,P>0.05).결론 파금삼정지성진전화자세성진전가능존재착불동적진전발생궤제,파금삼진전강도적역변성도치진전빈솔여강도지간불구유선성상관성,약물치료지능완해파금삼진전적증상,이대도치파금삼진전적중추성진탕기불구유역전성작용.
Objective To investigate the electromyngraphy eharacteristies of Parkinsen's disease (PD) by studying tremor frequency, intensity and drug response. Methods Sixty-six patients with PD hospitalized during March 2005 to May 2006 were re-evaluated and recruited into the study. A ten-channel electromyography recorded the frequency and intensity of the rest tremor and postural tremor. Tremor analysis soft was used to statistically analyze differences between the two types of tremor, correlation between the frequency and intensity, and changes after regular administration of dopaminergic medication. Results The frequencies of rest tremor ((4. 79±0.69 ) Hz) and postural tremor ( (5.54±1.18) Hz ) showed statistical differences (F = 33.5, P<0. 01), but the intensity of rest tremor (0.016-421.700 (rag)2) and postural tremor (0.062-217.900 (mg)2) didn't show statistical differences (F=1.917, P>0.05 ). No regression relation was revealed between the frequency and intensity of tremor (r=0.09, P>0.05). After dopaminergic medication treatment, the intensity declined significantly from 0.016-421.700 (mg)2 to 0.027-82.200 (mg)2(F=5.179,P <0.05), but the difference of frequencies of tremor between before ( (5.09±0.85) Hz) and after treatment ( (5.20 ± 1.08 )Hz) was not significant (F = 0.474, P > 0.05). Conclusions There may be different mechanisms for the rest tremor and postural tremor in PD. There is no correlation identified between the frequency and intensity in PD and this is may be resulted from variability of tremor intensity. Dopaminergic can relieve the symptom of tremor, but it doesn't reduce the frequency of tremor.
