中华医学遗传学杂志
中華醫學遺傳學雜誌
중화의학유전학잡지
CHINESE JOURNAL OF MEDICAL GENETICS
2011年
5期
539-542
,共4页
焦李子%王彬%牛晓蓉%马旭东%李建鹏%沈博%黄艳丽%张欢%张蕊%马捷
焦李子%王彬%牛曉蓉%馬旭東%李建鵬%瀋博%黃豔麗%張歡%張蕊%馬捷
초리자%왕빈%우효용%마욱동%리건붕%침박%황염려%장환%장예%마첩
精神分裂症%FXYD6基因%传递不平衡检验%单核苷酸多态性%单倍型
精神分裂癥%FXYD6基因%傳遞不平衡檢驗%單覈苷痠多態性%單倍型
정신분렬증%FXYD6기인%전체불평형검험%단핵감산다태성%단배형
schizophrenia%FXYD6 gene%transmission disequilibrium test%single nucleotide polymorphism%haplotype
目的 探讨FXYD6基因单核苷酸多态性(single nucleotide polymorphisms,SNP)和精神分裂症(schizophrenia)之间的相关性.方法 采用等位基因特异性PCR的方法对FXYD6基因6个SNPs(rs10790212、rs11544201、rs555577、rs1815774、rs4938446和rs497768)位点的基因型在101个三口之家中进行传递不平衡检验(transmission disequilibrium test,TDT).结果 遗传标记rs10790212和rs11544201显示了显著的传递不平衡(P＜0.05),而单倍型分析的结果表明单倍型rs10790212-rs11544201与精神分裂症显著性关联(P＜0.05).结论 FXYD6基因与中国汉族人群精神分裂症遗传易感性相关,有必要进一步开展对FXYD6基因的功能学研究.
目的 探討FXYD6基因單覈苷痠多態性(single nucleotide polymorphisms,SNP)和精神分裂癥(schizophrenia)之間的相關性.方法 採用等位基因特異性PCR的方法對FXYD6基因6箇SNPs(rs10790212、rs11544201、rs555577、rs1815774、rs4938446和rs497768)位點的基因型在101箇三口之傢中進行傳遞不平衡檢驗(transmission disequilibrium test,TDT).結果 遺傳標記rs10790212和rs11544201顯示瞭顯著的傳遞不平衡(P＜0.05),而單倍型分析的結果錶明單倍型rs10790212-rs11544201與精神分裂癥顯著性關聯(P＜0.05).結論 FXYD6基因與中國漢族人群精神分裂癥遺傳易感性相關,有必要進一步開展對FXYD6基因的功能學研究.
목적 탐토FXYD6기인단핵감산다태성(single nucleotide polymorphisms,SNP)화정신분렬증(schizophrenia)지간적상관성.방법 채용등위기인특이성PCR적방법대FXYD6기인6개SNPs(rs10790212、rs11544201、rs555577、rs1815774、rs4938446화rs497768)위점적기인형재101개삼구지가중진행전체불평형검험(transmission disequilibrium test,TDT).결과 유전표기rs10790212화rs11544201현시료현저적전체불평형(P＜0.05),이단배형분석적결과표명단배형rs10790212-rs11544201여정신분렬증현저성관련(P＜0.05).결론 FXYD6기인여중국한족인군정신분렬증유전역감성상관,유필요진일보개전대FXYD6기인적공능학연구.
Objective To study the association between the single nucleotide polymorphisms (SNPs) in FXYD6 gene and schizophrenia in a family-trios population. Methods Six SNPs (rs10790212,rs11544201,rs555577,rs1815774,rs4938446 and rs497768) in the FXYD6 gene were genotyped by allele-specific PCR method in 101 nuclear families,and transmission disequilibrium test (TDT) was performed.Results SNPs rs10790212 and rs11544201 showed significant association with schizophrenia (P＜0.05).Furthermore,significant association of schizophrenia with the haplotype rs10790212-rs11544201 was found (P＜0.05).Conclusion FXYD6 gene might play an important role in schizophrenia susceptibility and functional analysis of FXYD6 are needed.
