中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2010年
27期
1886-1889
,共4页
帕金森病%非运动症状
帕金森病%非運動癥狀
파금삼병%비운동증상
Parkinson's disease%Non-motor symptoms
目的 研究帕金森病(PD)患者的非运动症状(NMS)的分布状况和影响因素.方法 收集2007年1月至2009年3月北京医院门诊就诊的111例PD患者及46名健康对照,对其进行NMS问卷调查,比较两组各项NMS的分布,并结合临床特征等因素分析NMS发生的主要影响因素.结果 PD组的NMS-T(NMS总数)明显高于对照组.平均每例PD患者有12项NMS,并且随病情的加重而增多.UPDRS-Ⅲ(统一帕金森病评定量表第三部分)、左旋多巴剂量、年龄与NMS.T正相关,对NMS-T的决定作用占26.9%.左旋多巴剂量、Hoehn.Yahr分级、UPDRS-Ⅲ、NMS.T与UPDRS-II(统一帕金森病评定量表第二部分)正相关,对UPDRS-Ⅱ的决定作用占70.3%.结论 PD患者的NMS发生率明显高于对照组;NMS分布于各期PD患者,且随着病情的加重及年龄的增长而增多;NMS对PD患者的生活质量有很大影响.
目的 研究帕金森病(PD)患者的非運動癥狀(NMS)的分佈狀況和影響因素.方法 收集2007年1月至2009年3月北京醫院門診就診的111例PD患者及46名健康對照,對其進行NMS問捲調查,比較兩組各項NMS的分佈,併結閤臨床特徵等因素分析NMS髮生的主要影響因素.結果 PD組的NMS-T(NMS總數)明顯高于對照組.平均每例PD患者有12項NMS,併且隨病情的加重而增多.UPDRS-Ⅲ(統一帕金森病評定量錶第三部分)、左鏇多巴劑量、年齡與NMS.T正相關,對NMS-T的決定作用佔26.9%.左鏇多巴劑量、Hoehn.Yahr分級、UPDRS-Ⅲ、NMS.T與UPDRS-II(統一帕金森病評定量錶第二部分)正相關,對UPDRS-Ⅱ的決定作用佔70.3%.結論 PD患者的NMS髮生率明顯高于對照組;NMS分佈于各期PD患者,且隨著病情的加重及年齡的增長而增多;NMS對PD患者的生活質量有很大影響.
목적 연구파금삼병(PD)환자적비운동증상(NMS)적분포상황화영향인소.방법 수집2007년1월지2009년3월북경의원문진취진적111례PD환자급46명건강대조,대기진행NMS문권조사,비교량조각항NMS적분포,병결합림상특정등인소분석NMS발생적주요영향인소.결과 PD조적NMS-T(NMS총수)명현고우대조조.평균매례PD환자유12항NMS,병차수병정적가중이증다.UPDRS-Ⅲ(통일파금삼병평정량표제삼부분)、좌선다파제량、년령여NMS.T정상관,대NMS-T적결정작용점26.9%.좌선다파제량、Hoehn.Yahr분급、UPDRS-Ⅲ、NMS.T여UPDRS-II(통일파금삼병평정량표제이부분)정상관,대UPDRS-Ⅱ적결정작용점70.3%.결론 PD환자적NMS발생솔명현고우대조조;NMS분포우각기PD환자,차수착병정적가중급년령적증장이증다;NMS대PD환자적생활질량유흔대영향.
Objective To assess the characteristics and influencing factors of non-motor symptoms (NMS) in patients with Parkinson's disease(PD). Methods A total of 111 patients with PD and 46 healthy controls (HC) matched with age, gender, education status and occupation were investigated by NMS questionnaire. They were all outpatients of Beijing hospital. The distribution of NMS items was analyzed between two groups. And their clinical characteristics were also collected to assess the dominant influencing factors for the prevalence of NMS. Results There was significant difference in the prevalence of NMS between two groups (P<0. 01). Each PD patient had an average of 12 NMS throughout the disease stages and the number of NMS was increasing with the degree of disease severity. UPDRS-Ⅲ (united Parkinson's disease rating scale) , daily dose of levodopa and age showed a positive correlation with NMS-T ( NMS Total) and they accounted for 26.9% of the variance of NMS-T. Daily dose of levodopa, Hoehn-Yahr stage, UPDRS-Ⅲ and NMS-T showed a positive correlation with UPDRS- Ⅱ and they accounted for 70. 3% variance of UPDRS- Ⅱ. Conclusion NMS are more commonly seen in PD patients than in controls. NMS is present throughout every stages of PD and its number increases with the degree of disease severity and age. The quality of life is impaired significantly by NMS in PD patients.
