CAJ | 학술논문

目的深入了解光动力疗法与三羟异黄酮协同应用对荷瘤小鼠肿瘤生长抑制的作用特点.方法通过建立荷瘤小鼠动物模型,以光动力疗法和三羟异黄酮单独及协同应用后检测其抑瘤率及延命率,比较各组差异有无统计学意义.结果光动力疗法与三羟异黄酮的联合应用较光动力疗法或三羟异黄酮的单独作用更为显著的延缓荷瘤小鼠肿瘤体积的增长并延长荷瘤小鼠的生存时间.结论在体内实验中,三羟异黄酮能显著增强光动力疗法抗肿瘤作用疗效.
목적 심입료해광동력요법여삼간이황동협동응용대하류소서종류생장억제적작용특점.방법 통과건립하류소서동물모형,이광동력요법화삼간이황동단독급협동응용후검측기억류솔급연명솔,비교각조차이유무통계학의의.결과 광동력요법여삼간이황동적연합응용교광동력요법혹삼간이황동적단독작용경위현저적연완하류소서종류체적적증장병연장하류소서적생존시간.결론 재체내실험중,삼간이황동능현저증강광동력요법항종류작용료효.
Objective To investigate the therapy responsiveness by photedynamic therapy combined with GEN in vivo. Methods The mice bearing H22 xenografts were treated with PDT and GEN, the tumor inhibition effect was assessed by meas-uring gross tumor volumes and survival time over a period of 3 weeks, to know whether there is significant difference in each group. Results The combinations of Plyr with GEN could slow down the increase of tumor volumes and prolong the survival peri-od of mice bearing xenografts more significantly than PDT or GEN alone. Conclusion The treatment of protein tyrosine kinase inhibitor,genistein(GEN) ,can enhance the photodynamic therapy responsiveness in a mouse hepatocellular carcinoma(H22) in vivo.