CAJ | 학술논문

蛋白质糖基化是一种最常见也是最复杂的蛋白质翻译后修饰过程,是指蛋白质或脂质附加上聚糖的过程.糖蛋白的聚糖部分的重要功能之一是维持多细胞生物体细胞的稳态.糖基化过程在外界生物化学环境的影响下会发生改变,包括生理条件的改变和某些特殊疾病状况例如癌症,从而导致糖链结构的改变.目前由于传统癌症标志物灵敏度和特异度较低,导致癌症不能在疾病早期阶段被识别,寻找新的癌症诊断标志物成为癌症研究的重要方向之一.近年来,糖基组学技术的进步为深入分析糖链结构提供了有力条件.因此,寻找合适的糖基作为癌症诊断的新的标志物成为癌症研究的热点.本篇综述阐释了聚糖作为癌症诊断标志物这一研究方向的进展状况.
단백질당기화시일충최상견야시최복잡적단백질번역후수식과정,시지단백질혹지질부가상취당적과정.당단백적취당부분적중요공능지일시유지다세포생물체세포적은태.당기화과정재외계생물화학배경적영향하회발생개변,포괄생리조건적개변화모사특수질병상황례여암증,종이도치당련결구적개변.목전유우전통암증표지물령민도화특이도교저,도치암증불능재질병조기계단피식별,심조신적암증진단표지물성위암증연구적중요방향지일.근년래,당기조학기술적진보위심입분석당련결구제공료유력조건.인차,심조합괄적당기작위암증진단적신적표지물성위암증연구적열점.본편종술천석료취당작위암증진단표지물저일연구방향적진전상황.
Glycosylation, links the glycan chains to protein or lipid, is the most common and complex post-translational modifications of proteins. One of the important functions of glycans is to maintain the ordered social life of each cell in multi-cellular organisms. Glycosylation is sensitive to the biochemical environment leading to the alternation of glycan chains under physiological condition and specific diseases such as cancer. Up to date, cancer and other lethal diseases could not be diagnosed at early stage because of the traditional marker's low sensitivity and less specificity. Recent years, the development of glycan profiling technologies has offered technology support for understanding the complex glycan structures and has increased great interest in applying the technology for cancer studies. In this regard, to identify the glycans as the potential biomarkers of cancer has become an important direction for clinical cancer diagnosis. This review summarizes the current research on finding the glycans as new cancer biomarkers.