中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2009年
15期
6-8
,共3页
C反应蛋白质%慢性病%肾透析%营养不良
C反應蛋白質%慢性病%腎透析%營養不良
C반응단백질%만성병%신투석%영양불량
C-reactive protein%Chronic disease%Renal dialysis%Malnutrition
目的 探讨慢性肾脏病(CKD)5期患者机体炎性反应和营养状态的变化及其相互关系.方法 90例CKD 5期患者分为非透析(ND)组、血液透析(MHD)组和腹膜透析(CAPD)组,每组各30例,检测其炎性反应指标血浆高敏C反应蛋白(hs-CRP)和营养指标(血浆白蛋白、血红蛋白),并与30例健康体检者(健康对照组)进行比较.结果CKD 5期患者血浆hs-CRP水平高于健康对照组(P<0.01),MHD组和CAPD组患者血浆hs-CRP水平均高于ND组(P<0.05),MHD组与CAPD组患者血浆hs-CRP水平比较差异无统计学意义.血浆白蛋白<35 g/L和血红蛋白<90 g/L的CKD 5期患者血浆hs-CRP增高更为明显,且血浆hs-CRP水平与血浆白蛋白和血红蛋白呈负相关(r=-0.535,P<0.01;r=-0.220,P<0.05).结论 CKD 5期患者血浆hs-CRP水平增高,且与血浆白蛋白和血红蛋白之间存在负相关,炎性反应可能是导致或加重CKD患者营养不良的原因之一.
目的 探討慢性腎髒病(CKD)5期患者機體炎性反應和營養狀態的變化及其相互關繫.方法 90例CKD 5期患者分為非透析(ND)組、血液透析(MHD)組和腹膜透析(CAPD)組,每組各30例,檢測其炎性反應指標血漿高敏C反應蛋白(hs-CRP)和營養指標(血漿白蛋白、血紅蛋白),併與30例健康體檢者(健康對照組)進行比較.結果CKD 5期患者血漿hs-CRP水平高于健康對照組(P<0.01),MHD組和CAPD組患者血漿hs-CRP水平均高于ND組(P<0.05),MHD組與CAPD組患者血漿hs-CRP水平比較差異無統計學意義.血漿白蛋白<35 g/L和血紅蛋白<90 g/L的CKD 5期患者血漿hs-CRP增高更為明顯,且血漿hs-CRP水平與血漿白蛋白和血紅蛋白呈負相關(r=-0.535,P<0.01;r=-0.220,P<0.05).結論 CKD 5期患者血漿hs-CRP水平增高,且與血漿白蛋白和血紅蛋白之間存在負相關,炎性反應可能是導緻或加重CKD患者營養不良的原因之一.
목적 탐토만성신장병(CKD)5기환자궤체염성반응화영양상태적변화급기상호관계.방법 90례CKD 5기환자분위비투석(ND)조、혈액투석(MHD)조화복막투석(CAPD)조,매조각30례,검측기염성반응지표혈장고민C반응단백(hs-CRP)화영양지표(혈장백단백、혈홍단백),병여30례건강체검자(건강대조조)진행비교.결과CKD 5기환자혈장hs-CRP수평고우건강대조조(P<0.01),MHD조화CAPD조환자혈장hs-CRP수평균고우ND조(P<0.05),MHD조여CAPD조환자혈장hs-CRP수평비교차이무통계학의의.혈장백단백<35 g/L화혈홍단백<90 g/L적CKD 5기환자혈장hs-CRP증고경위명현,차혈장hs-CRP수평여혈장백단백화혈홍단백정부상관(r=-0.535,P<0.01;r=-0.220,P<0.05).결론 CKD 5기환자혈장hs-CRP수평증고,차여혈장백단백화혈홍단백지간존재부상관,염성반응가능시도치혹가중CKD환자영양불량적원인지일.
Objective To explore the variation of the plasma high-sensitive C reactive protein (hs-CRP) levels and analyze the relationship between inflammation and malnutrition in the patients with stage V chronic kidney disease (CKD). Methods Ninety patients with stage V CKD were enrolled. The patients were divided into three groups according to their treatment, no dialysis (ND) group, hemodialysis (MHD) group and continuous ambulatory peritoneal dialysis (CAPD) group. Plasma hs-CRP, albumin and hemoglobin were detected. Results The levels of plasma hs-CRP were significantly increased in the patients with stage V CKD compared with normal individuals (P< 0.01). It showed a significant difference between MHD group, CAPD group and ND group (P < 0.05), while no significant difference was found between MHD group and CAPD group. The plasma hs-CRP levels increased in the patients with lower plasma albumin (< 35 g/L) or lower hemoglobin (< 90 g/L). Levels of plasma hs-CRP showed a negative relationship with plasma albumin and hemoglobin (r =- 0.535, P < 0.01 ;r =-0.220, P < 0.05). Conclusions Plasma hs-CRP levels increase in patients with stage V CKD, and there is a negative relationship between hs-CRP and plasma albumin and hemoglobin. Inflammation may be a factor of malnutrition in patients with CKD.
