CAJ | 학술논문

目的通过检测食管癌、癌旁组织细胞凋亡率,探讨食管癌组织细胞凋亡与患者生存期的关系.方法收集68例手术食管癌患者的食管癌组织、癌旁组织和28例正常食管黏膜组织标本,应用流式细胞技术检测细胞凋亡率,并对63例患者进行1、3年生存期随访.结果细胞凋亡率在正常食管黏膜组织中为(12.78±1.32)%,癌旁组织为(7.79±1.48)%,食管癌组织为(4.16±2.06)%,各组织间比较差异均有统计学意义(P<0.05).随访结果显示,生存期1年60例、生存期3年35例;生存期1年患者食管癌组织和癌旁组织细胞凋亡率分别为(3.45±1.51)%和(3.96±0.94)%;生存期3年患者食管癌组织和癌旁组织细胞凋亡率分别为(3.90±2.53)%和(7.89±2.27)%.生存期1年和3年患者癌旁组织细胞凋亡率比较差异有统计学意义(P<0.05),而食管癌组织细胞凋亡率比较差异无统计学意义.结论食管癌在发生和发展过程中癌细胞也存在凋亡逃逸现象;食管癌组织细胞凋亡与患者生存期有一定的关系.癌旁组织细胞凋亡程度比食管癌组织中的细胞凋亡现象在食管癌的发生及预后评估中更为重要.
목적 통과검측식관암、암방조직세포조망솔,탐토식관암조직세포조망여환자생존기적관계.방법 수집68례수술식관암환자적식관암조직、암방조직화28례정상식관점막조직표본,응용류식세포기술검측세포조망솔,병대63례환자진행1、3년생존기수방.결과 세포조망솔재정상식관점막조직중위(12.78±1.32)%,암방조직위(7.79±1.48)%,식관암조직위(4.16±2.06)%,각조직간비교차이균유통계학의의(P<0.05).수방결과현시,생존기1년60례、생존기3년35례;생존기1년환자식관암조직화암방조직세포조망솔분별위(3.45±1.51)%화(3.96±0.94)%;생존기3년환자식관암조직화암방조직세포조망솔분별위(3.90±2.53)%화(7.89±2.27)%.생존기1년화3년환자암방조직세포조망솔비교차이유통계학의의(P<0.05),이식관암조직세포조망솔비교차이무통계학의의.결론 식관암재발생화발전과정중암세포야존재조망도일현상;식관암조직세포조망여환자생존기유일정적관계.암방조직세포조망정도비식관암조직중적세포조망현상재식관암적발생급예후평고중경위중요.
Objective To explore the relationship between the apoptosis of esophageal carcinoma tissue and its adjacent tissues with the survival time of patients with esophageal carcinoma by examining the apoptosis in esophageal carcinoma tissue and its adjacent tissues.Methods FCM Wag performed to detect the rates of apoptosis in 68 cases of esophageal carcinoma and their adjacent tissues and 28 cases of normal esophageal mucosae tissue.Sixty-three patients with esophageal carcinoma had been followed up and noted the survival time of every patient from the operated day to the deadline.Results The rate of apoptosis was the highest in the normal esophageal mucosae tissue(12.78±1.32)%,(7.79±1.48)% in adjacent tissue,and(4.16±2.06)% in esophageal carcinoma tissue,respectively.To follow the survival time after operation of 63 cases with esophageal carcinoma showed 60 cases in one year survival time and 35 cases in three years survival time.The rate of apoptosis in the esophageal carcinoma and its adjacent tissues wag(3.45±1.51)% and (3.96±0.94)% in the patients of one year survival time,(3.90±2.53)% and (7.89±2.27)% in the patients of three years survival time,respectively,P<0.05.Conclusions There is the phenomenon of apoptosis-escape in the esophageal carcinogenesis.There is close relationship between the apoptosis of esophageal carcinoma tissue and the survival time after operation.The apoptosis in the adjacent tissue is more important than that in the esophageal carcinoma tissue for evaluating the survival time after operation of patients with esophageal carcinoma.