CAJ | 학술논문

目的肝移植病人术后乙肝复发的临床随访观察.方法复诊与随访表调查.结果拉米呋啶和HBIG联用的情况下,8个分中心的182例肝移植病人术后19个月随访期的乙肝复发率为0.55%.若将术后1周内230个研究病例中血清HBsAg未阴转的9个病例(3.91%)视为乙肝复发病例,术后19个月试验与对照组复发率分别为6.89%(6/87),4.21(4/95).采用循证医学方法,分析世界范围内单用HBIG、拉米呋啶及拉米呋啶和HBIG联用3种方法,认为均有不同程度防治肝移植病人术后乙肝复发的效果.结论该次临床随访时间与多数的历史文献对照观察时间点形成重叠,临床研究与随访的乙肝复发率与既往文献结果吻合,拉米呋啶和HBIG联用是较优的防治策略.
목적 간이식병인술후을간복발적림상수방관찰.방법 복진여수방표조사.결과 랍미부정화HBIG련용적정황하,8개분중심적182례간이식병인술후19개월수방기적을간복발솔위0.55%.약장술후1주내230개연구병례중혈청HBsAg미음전적9개병례(3.91%)시위을간복발병례,술후19개월시험여대조조복발솔분별위6.89%(6/87),4.21(4/95).채용순증의학방법,분석세계범위내단용HBIG、랍미부정급랍미부정화HBIG련용3충방법,인위균유불동정도방치간이식병인술후을간복발적효과.결론 해차림상수방시간여다수적역사문헌대조관찰시간점형성중첩,림상연구여수방적을간복발솔여기왕문헌결과문합,랍미부정화HBIG련용시교우적방치책략.
Objective To follow up the hepatitis B recurrence after liver transplantation. Meth-ods Further consultation with doctors and clinical follow-up investigation were conducted. Results After treatment with the lamivudine in combination with hepatitis B immunoglobulin (HBIG) prophy-laxis for 19 months after liver transplanation, 182 patients in 8 medical centers had a hepatitis B re-currence rate of 0.55 %. If we regarded 9 patients of 230 study cases (3.91%) with serum HBsAg se-ropositivity during the course of 1 week after liver transplantation to be the hepatitis B recurrence ca-ses, hepatitis B recurrence rate of the trial and control group was 6.89%(6/87) and 4.21(4/95), re-spectively. Depending on worldwide bibliographic database analysis, it is generally believed that using lamivudine or HBIG alone, using ]amivudine in combination with HBIG, or using all 3 Method have prophylaxis effectiveness to hepatitis B recurrence after liver transplantation, which differ only in de-gree. Conclusion The time of follow-up investigation overlaps with majority document published.The hepatitis B recurrence rate of clinical study and follow-up investigation are similar with Results of document published. Lamivudine in combination with HBIG is better than using lamivudine or HBIG alone.