中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2009年
2期
92-96
,共5页
邓玲珑%张志珺%宇辉%施咏梅
鄧玲瓏%張誌珺%宇輝%施詠梅
산령롱%장지군%우휘%시영매
老年人%认知障碍%遗忘%基因%多态性,限制性片段长度%肽基二肽酶A
老年人%認知障礙%遺忘%基因%多態性,限製性片段長度%肽基二肽酶A
노년인%인지장애%유망%기인%다태성,한제성편단장도%태기이태매A
Agd%Cognition disorders%Amnesia%Genes%Polymorphism,restrictionfragment length%Peptidyl-dipeptidase A
目的 探讨遗忘型轻度认知障碍(aMCI)与血管紧张素转换酶(ACE)基因插入和缺失(I/D)多态性及血清ACE活力水平的关系.方法 对符合美国Meyo诊所Petersen等制定的aMCI诊断标准的90例aMCI患者(aMC[组)及90名与aMCI组相匹配正常对照者(对照组)进行神经认知功能评估,并应用聚合酶链反应检测ACE基因I/D多态性,用紫外分光光度法检测血清ACE活力水平.结果 (1)aMCI组的各项神经认知测试成绩均差于对照组(P<0.01).(2)aMCI组ACE基因型(χ2=1.510)及等位基因频率(χ2=6.945)与对照组的差异均有统计学意义(P<0.01),其中aMCI组DD基因型(23%)及D等位基因频率(57%)高于对照组(分别为16%和43%).(3)两组DD基因型(n=35)及DI基因趔(n=109)者的听觉词语记忆、符号数宁转换测试、复杂图形及类别词语流畅性得分低于Ⅱ基因型者(n=36;均P<0.05-0.01).(4)aMCI组(F=7.491)和对照组(F=4.970)ACE基因型各亚组问血清ACE活力水平的差异均有统计学意义(P<0.01),两组ACE活力水平均为DD型组>DI型组>II型组.(5)aMCI组血清ACE活力与听觉词语记忆测试的延迟回忆得分呈负相关(r=-0.249,P<0.05).结论 D等位基因可能为aMCI的发病危险因子,其调控的血清ACE高活力水平与aMCI患者情节记忆损害有关.
目的 探討遺忘型輕度認知障礙(aMCI)與血管緊張素轉換酶(ACE)基因插入和缺失(I/D)多態性及血清ACE活力水平的關繫.方法 對符閤美國Meyo診所Petersen等製定的aMCI診斷標準的90例aMCI患者(aMC[組)及90名與aMCI組相匹配正常對照者(對照組)進行神經認知功能評估,併應用聚閤酶鏈反應檢測ACE基因I/D多態性,用紫外分光光度法檢測血清ACE活力水平.結果 (1)aMCI組的各項神經認知測試成績均差于對照組(P<0.01).(2)aMCI組ACE基因型(χ2=1.510)及等位基因頻率(χ2=6.945)與對照組的差異均有統計學意義(P<0.01),其中aMCI組DD基因型(23%)及D等位基因頻率(57%)高于對照組(分彆為16%和43%).(3)兩組DD基因型(n=35)及DI基因趔(n=109)者的聽覺詞語記憶、符號數寧轉換測試、複雜圖形及類彆詞語流暢性得分低于Ⅱ基因型者(n=36;均P<0.05-0.01).(4)aMCI組(F=7.491)和對照組(F=4.970)ACE基因型各亞組問血清ACE活力水平的差異均有統計學意義(P<0.01),兩組ACE活力水平均為DD型組>DI型組>II型組.(5)aMCI組血清ACE活力與聽覺詞語記憶測試的延遲迴憶得分呈負相關(r=-0.249,P<0.05).結論 D等位基因可能為aMCI的髮病危險因子,其調控的血清ACE高活力水平與aMCI患者情節記憶損害有關.
목적 탐토유망형경도인지장애(aMCI)여혈관긴장소전환매(ACE)기인삽입화결실(I/D)다태성급혈청ACE활력수평적관계.방법 대부합미국Meyo진소Petersen등제정적aMCI진단표준적90례aMCI환자(aMC[조)급90명여aMCI조상필배정상대조자(대조조)진행신경인지공능평고,병응용취합매련반응검측ACE기인I/D다태성,용자외분광광도법검측혈청ACE활력수평.결과 (1)aMCI조적각항신경인지측시성적균차우대조조(P<0.01).(2)aMCI조ACE기인형(χ2=1.510)급등위기인빈솔(χ2=6.945)여대조조적차이균유통계학의의(P<0.01),기중aMCI조DD기인형(23%)급D등위기인빈솔(57%)고우대조조(분별위16%화43%).(3)량조DD기인형(n=35)급DI기인렬(n=109)자적은각사어기억、부호수저전환측시、복잡도형급유별사어류창성득분저우Ⅱ기인형자(n=36;균P<0.05-0.01).(4)aMCI조(F=7.491)화대조조(F=4.970)ACE기인형각아조문혈청ACE활력수평적차이균유통계학의의(P<0.01),량조ACE활력수평균위DD형조>DI형조>II형조.(5)aMCI조혈청ACE활력여은각사어기억측시적연지회억득분정부상관(r=-0.249,P<0.05).결론 D등위기인가능위aMCI적발병위험인자,기조공적혈청ACE고활력수평여aMCI환자정절기억손해유관.
Objective To study the relationship among amnestic mild cognitive impairment(aMCI)and the angiotensin-converting enzyme(ACE)gene polymorphism of intron 16 insertion/deletion(I/D)and serum ACE level.Methods One hundred and eighty subjects(60-85 years)were divided into aMCI group(n=90)and normal control group(n=90)through a series of neuropsychologcal evaluating.The intron 16 I/D polymorphism of ACE gene was analyzed by means of polymerase chain reaction(PCR).The serum ACE levels were measured by using ultraviolet spectrophotometry.Results The scores of neuropsychological tests in aMCI patients were significantly poorer than that in controls(all P＜0.01).The frequencies of DD genotype and D aliele of ACE gene were significantly different between aMCI patients and controls(all P＜0.01).The frequencies of DD genotype and D allele were higher in aMCI patients than controls(23%vs.16%;57%vs.43%).ACE genotype was correlated with delayed recall in Auditory Verbal Memory Test(AVMT),delay recall in Complex Figure Test,Category Fluency Test and Symbol Digit Modalities Test(all P＜0.05),in which DD and DI genotype was lower than Ⅱ genotype(P＜0.05).A significant difference in serum ACE level was observed among the three genotypes in both aMCI and control group(DD＞DI＞II;P＜0.01).AVMT-delay recall had significant correlations with serom ACE level in aMCI group(r=-0.249,P＜0.05).Conclusions The ACE gene I/D polymorphism may be correlated with aMCI,with D allele possibly being a genetic risk factor for the development of aMCI.The higher serum ACE level my possibly play a role in the episodic memory impairment of aMCI.
