中华内分泌外科杂志
中華內分泌外科雜誌
중화내분비외과잡지
CHINESE JOURNAL OF ENDOCRINE SURGERY
2009年
1期
16-18
,共3页
杨光伦%历红元%涂刚%吴诚义
楊光倫%歷紅元%塗剛%吳誠義
양광륜%력홍원%도강%오성의
乳腺癌%前哨淋巴结活检%新辅助化疗
乳腺癌%前哨淋巴結活檢%新輔助化療
유선암%전초림파결활검%신보조화료
Breast cancer%Sentinel lymph node%Neoadjuvant chemotherapy
目的 比较研究乳腺癌新辅助化疗对前哨淋巴结活检及腋窝淋巴结状况的影响.方法 对2005年6月至2007年6月165例Ⅰ、Ⅱa、Ⅱb、Ⅲ期乳腺癌行99mTc联合亚甲蓝示踪剂注射后前哨淋巴结活检术,再行腋窝淋巴结清扫术;其中65例Ⅱb、Ⅲ期先行3个疗程新辅助化疗后再行前哨淋巴活检及腋窝淋巴结清扫术,另100例Ⅰ、Ⅱa期直接行前哨淋巴结活检及腋窝淋巴结清扫.结果 行新辅助化疗组和未行新辅助化疗组每例平均腋窝淋巴结检出数分别为14.60枚和14.74枚(P＞0.05)、前哨淋巴结数分别为1.46枚和1.5枚(P＞0.05)、SLN检出率分别为96.7%和96.9%(P＞0.05)、SLN假阴性率分别为4.6%和4%(P＞0.05).结论 新辅助化疗后乳腺癌腋窝淋巴结检出数、前哨淋巴结的确认率和假阴性率与未行新辅助化疗患者的结果一致,新辅助化疗后前哨淋巴结活检能准确预测腋窝淋巴结的状况.
目的 比較研究乳腺癌新輔助化療對前哨淋巴結活檢及腋窩淋巴結狀況的影響.方法 對2005年6月至2007年6月165例Ⅰ、Ⅱa、Ⅱb、Ⅲ期乳腺癌行99mTc聯閤亞甲藍示蹤劑註射後前哨淋巴結活檢術,再行腋窩淋巴結清掃術;其中65例Ⅱb、Ⅲ期先行3箇療程新輔助化療後再行前哨淋巴活檢及腋窩淋巴結清掃術,另100例Ⅰ、Ⅱa期直接行前哨淋巴結活檢及腋窩淋巴結清掃.結果 行新輔助化療組和未行新輔助化療組每例平均腋窩淋巴結檢齣數分彆為14.60枚和14.74枚(P＞0.05)、前哨淋巴結數分彆為1.46枚和1.5枚(P＞0.05)、SLN檢齣率分彆為96.7%和96.9%(P＞0.05)、SLN假陰性率分彆為4.6%和4%(P＞0.05).結論 新輔助化療後乳腺癌腋窩淋巴結檢齣數、前哨淋巴結的確認率和假陰性率與未行新輔助化療患者的結果一緻,新輔助化療後前哨淋巴結活檢能準確預測腋窩淋巴結的狀況.
목적 비교연구유선암신보조화료대전초림파결활검급액와림파결상황적영향.방법 대2005년6월지2007년6월165례Ⅰ、Ⅱa、Ⅱb、Ⅲ기유선암행99mTc연합아갑람시종제주사후전초림파결활검술,재행액와림파결청소술;기중65례Ⅱb、Ⅲ기선행3개료정신보조화료후재행전초림파활검급액와림파결청소술,령100례Ⅰ、Ⅱa기직접행전초림파결활검급액와림파결청소.결과 행신보조화료조화미행신보조화료조매례평균액와림파결검출수분별위14.60매화14.74매(P＞0.05)、전초림파결수분별위1.46매화1.5매(P＞0.05)、SLN검출솔분별위96.7%화96.9%(P＞0.05)、SLN가음성솔분별위4.6%화4%(P＞0.05).결론 신보조화료후유선암액와림파결검출수、전초림파결적학인솔화가음성솔여미행신보조화료환자적결과일치,신보조화료후전초림파결활검능준학예측액와림파결적상황.
Objective Comparing the influence of neoadjuvant chemotherapy on sentinel lymph node biopsy and axillary lymph nodal staging. Methods From June 2005 to June 2007 one hundred and sixty five breast cancer patients of stage Ⅰ,Ⅱa,Ⅱb and Ⅲ underwent sentinel lymph node biopsy(SLNB) using 99mTc combining methylene blue dye as tracer to help axillary lymph node dissection(AND) were retrospectively reviewed. Sixty five patients staged Ⅱb or Ⅲ were treated with three circles neoadjuvant chemotherapy prior to SLNB and AND , another one hundred patients staged ⅠorⅡa had SLNB and AND directly without neoadjuvant chemotherapy.Results Average 14.60 axillary lymph nodes were retrieved in patients had neoadjuvant chemotherapy and 14.74 lymph nodes in patients did not have neoadjuvant chemotherapy(P>0.05),a mean number of 1.46 sentinel lymph nodes in neoadjuvant chemotherapy group and 1.5 sentinel lymph nodes in non-neoadjuvant chemotherapy(P>0.05), sentinel lymph node identification rate 96.9% in neoadjuvant chemotherapy group and 97% in non-neoadjuvant chemotherapy(P>0.05), the false negative rate was 4.6% in neoadjuvant chemotherapy group and 4% in non-neoadjuvant chemotherapy group(P>0.05). Conclusions The mean number of lymph nodes,sentinel lymph nodes,SLN identification rate and false-negative rates after neoadjuvant chemotherapy are similar to those seen in patients without neoadjuvant chemotherapy.The SLNB can accurately predict lymph node status of axillary lymph node following neoadjuvant chemotherapy.
