CAJ | 학술논문

目的探讨含骨肉瘤成分的乳腺癌肉瘤的临床病理学特征、免疫表型、诊断及鉴别诊断要点.方法对2例含骨肉瘤成分的乳腺癌肉瘤的临床病理学资料进行回顾性分析,行免疫组化标记并复习文献.结果肿瘤由癌和骨肉瘤样成分构成,并可见癌与肉瘤性成分间的移行过渡.癌性成分为非特殊型浸润性导管癌,肉瘤性成分表现为低或高分化骨肉瘤.免疫组织化学染色显示:癌细胞中CK和EMA呈阳性表达,肉瘤性成分表达vimentin,癌和肉瘤性成分均有少数细胞表达S-100蛋白.例1癌及肉瘤性成分Ki-67和VEGF均呈高表达;例2癌及肉瘤性成分Ki-67均呈低表达,VEGF在肉瘤性成分呈高表达而在癌中呈低表达,部分癌细胞ER呈阳性.结论含骨肉瘤成分的乳腺癌肉瘤是一种罕见的乳腺上皮间叶混合性化生性癌,其诊断应分别标注癌及肉瘤的具体类型及比例.
목적 탐토함골육류성분적유선암육류적림상병이학특정、면역표형、진단급감별진단요점.방법 대2례함골육류성분적유선암육류적림상병이학자료진행회고성분석,행면역조화표기병복습문헌.결과 종류유암화골육류양성분구성,병가견암여육류성성분간적이행과도.암성성분위비특수형침윤성도관암,육류성성분표현위저혹고분화골육류.면역조직화학염색현시:암세포중CK화EMA정양성표체,육류성성분표체vimentin,암화육류성성분균유소수세포표체S-100단백.례1암급육류성성분Ki-67화VEGF균정고표체;례2암급육류성성분Ki-67균정저표체,VEGF재육류성성분정고표체이재암중정저표체,부분암세포ER정양성.결론 함골육류성분적유선암육류시일충한견적유선상피간협혼합성화생성암,기진단응분별표주암급육류적구체류형급비례.
Objective To investigate the clinicopathologic and immunohistochemical characteristics of breast carcinosarcoma with osteosarcoma components and its differential diagnosis. Methods The pathologic features and clinical manifestations of the two patients were retrospectively reviewed. Immunohistochemistry was performed and the literature was reviewed. Results Histopathologically, the neoplasm consisted of invasive ductal carcinoma of no special type and poorly ( case 1 ) or well (case 2) differentiated osteosarcomatoid elements. The morphological transition from carcinoma to sarcomatoid elements was seen. Immunohistochemically,the carcinoma cells were positive for CK and EMA , the sarcomatoid elements were stained positive for vimentin, and a few cells of two elements were positive for S-100 protein. Ki-67 and VEGF were over expressed in both elements of Case 1.In case2 Ki-67 expression was low in both elements and VEGF over expression was only seen in sarcomatoid elements. Some of the carcinoma cells were positive for ER. Conclusions Carcinosarcoma of the breast with osteosarcomatoid elements is a rare type of mixed epithelial/mesenchymal metaplastic breast carcinoma. The types and proportion of carcinoma and sarcomatoid elements determine the diagnosis.