CAJ | 학술논문

目的探讨应用超声心动图评价高效抗逆转录病毒治疗艾滋病的心血管安全性.方法应用超声心动图测量45例艾滋病患者高效抗逆转录病毒治疗前、治疗48周及96周心脏各房室腔内径、室壁厚度、瓣膜形态、瓣口血流速度、室壁运动速度、左心室缩短分数、射血分数.结果 45例艾滋病患者治疗前与治疗96周间、治疗48周与治疗96周间的左室流出道血流速度(V-LVOT)[( 115.0±13.8) cm/s比(107.0±13.3)cm/s,(113.0±12.9)cm/s比(107.0±13.3)cm/s]、二尖瓣口E峰减速时间(EDT)[( 166.8±26.7)ms比(140.4±19.3)ms,(172.9±31.0)ms比(140.4±19.3) ms],治疗前[(26.8±6.7)cm/s]与治疗48周[(23.8±5.0)cm/s]、治疗前与治疗96周间(22.7±6.4)cm/s的二尖瓣环处舒张早期运动速度(E’)差异均有统计学意义(均P ＜0.05),其余各项测值间差异均无统计学意义(均P＞0.05).结论高效抗逆转录病毒治疗艾滋病短期内具备心血管安全性,超声心动图可准确评价抗病毒治疗后心脏功能.
목적 탐토응용초성심동도평개고효항역전록병독치료애자병적심혈관안전성.방법 응용초성심동도측량45례애자병환자고효항역전록병독치료전、치료48주급96주심장각방실강내경、실벽후도、판막형태、판구혈류속도、실벽운동속도、좌심실축단분수、사혈분수.결과 45례애자병환자치료전여치료96주간、치료48주여치료96주간적좌실류출도혈류속도(V-LVOT)[( 115.0±13.8) cm/s비(107.0±13.3)cm/s,(113.0±12.9)cm/s비(107.0±13.3)cm/s]、이첨판구E봉감속시간(EDT)[( 166.8±26.7)ms비(140.4±19.3)ms,(172.9±31.0)ms비(140.4±19.3) ms],치료전[(26.8±6.7)cm/s]여치료48주[(23.8±5.0)cm/s]、치료전여치료96주간(22.7±6.4)cm/s적이첨판배처서장조기운동속도(E’)차이균유통계학의의(균P ＜0.05),기여각항측치간차이균무통계학의의(균P＞0.05).결론 고효항역전록병독치료애자병단기내구비심혈관안전성,초성심동도가준학평개항병독치료후심장공능.
Objective To explore the clinical value of echocardiography in evaluating the cardiovascular safety of drugs for AIDS patients treated by highly active antiretroviral therapy(HAART).Methods 45 HIV-infected patients accepted three times of echocardiography respectively before the treatment,and after 48 weeks of HAART and 96 weeks of HAART.All kinds of echocardiographic parameters were measured.Results There were statistically significant differences among baseline group pretreatment [V-LVOT:( 115.0 ± 13.8 ) cm/s,EDT:(166.8 ± 26.7) cm/s,E':(26.8±6.7)cm/s],48 weeks [V-LVOT:( 113.0 ± 12.9)cm/s,EDT:(172.9±31.0)cm/s,E':(23.8 ±5.0)cm/s] of HAART and96 weeks[V-LVOT:(107.0±13.3)cm/s,EDT:(140.4 ± 19.3)cm/s,E':(22.7±6.4)cm/s]of HAART for parameters of V-LVOT,EDT and E'( all P ＜ 0.05 ),other echocardiographic parameters showed no statistically significant differences(all P＞0.05).Conclusion Short-term of HAART was provided with cardiovascular safety,the invasive echocardiography could accurately evaluate the cardiac function and structure of AIDS patients with HAART.