CAJ | 학술논문

目的探讨在广州地区的糖尿病高风险人群中HbA1C与糖尿病微血管并发症之间的关系,并评价其对糖尿病的诊断价值.方法对208例糖尿病高风险患者进行HbA1C、血糖、眼底彩色照相及微量白蛋白尿测定.以受试者工作特征(ROC)曲线比较HbA1C、空腹血糖(FPG)、餐后2 h血糖(2hPG)的诊断效果.结果高风险人群中糖尿病视网膜病变患病率为14.9%,微量白蛋白尿患病率为12%.HbA1C、FPG和2hPG分别为5.8%、7.0 mmol/L和10.9 mmol/L时视网膜病变的发病率显著增加.HbA1C、FPG和2hPG分别为5.8%、6.4mmol/L和10.7mmol/L时微量白蛋白尿发病率明显增加.结论 HbA1C为5.8%时糖尿病高风险人群微血管并发症患病率显著增加,HbA1C和2hPG判断微血管并发症的效果无明显差异,FPG相对偏低.
목적 탐토재엄주지구적당뇨병고풍험인군중HbA1C여당뇨병미혈관병발증지간적관계,병평개기대당뇨병적진단개치.방법 대208례당뇨병고풍험환자진행HbA1C、혈당、안저채색조상급미량백단백뇨측정.이수시자공작특정(ROC)곡선비교HbA1C、공복혈당(FPG)、찬후2 h혈당(2hPG)적진단효과.결과 고풍험인군중당뇨병시망막병변환병솔위14.9%,미량백단백뇨환병솔위12%.HbA1C、FPG화2hPG분별위5.8%、7.0 mmol/L화10.9 mmol/L시시망막병변적발병솔현저증가.HbA1C、FPG화2hPG분별위5.8%、6.4mmol/L화10.7mmol/L시미량백단백뇨발병솔명현증가.결론 HbA1C위5.8%시당뇨병고풍험인군미혈관병발증환병솔현저증가,HbA1C화2hPG판단미혈관병발증적효과무명현차이,FPG상대편저.
Objective To explore the association of HbA1C with microvascular complications,and to evaluate the diagnostic value of HbA1C in diabetes mellitus in high-risk populations of Guangzhou.Methods HbA1C,blood glucose,fundus photography,and microalbuminuria were detected in 208 permanent residents with high-risk factors of diabetes.The receiver operating characteristiC(ROC)curves were used to estimate the area of HbA1C,fasting plasma glucose(FPG),postprandial 2 h plasma glucose(2hPG)under the curve for discriminating microvascular complications.Results There were 14.9% adults suffering from diabetic retinopathy and 12% microalbuminuria in high risk populations of diabetes.The optimal cutoff points of HbA1C,FPG,and 2hPG in detecting retinopathy were 5.8%,7.0 mmol/L,and 10.9 mmol/L respectively.The thresholds for increasing prevalence of microalbuminuria were5.8% for HbA1C,6.4 mmol/L for FPG,and 10.7 mmol/L for 2hPG.Conclusions The prevalence of diabetic microvascular complications increases dramatically at the concentration of HbA1C 5.8%.As a diagnostic value for microvascular complications,there is no significant difference between HbA1C and 2hPG.