CAJ | 학술논문

目的：探讨不稳定性心绞痛(UAP)患者心理社会因素与血小板聚集功能的关系。方法：采用6个心理量表对46例UAP患者和46例健康人进行评定，并测定ADP诱导的血小板聚集率。结果：UAP组负性生活事件刺激量、消极应对、CH、焦虑和抑郁积分及血小板聚集率均高于对照组(均P＜0.01)，社会支持总分和积极应对分低于对照组(均P＜0.01)，UAP组A型行为、焦虑及抑郁分别占73.91％、82.6％和71.4％，高于对照组36.96％、34.8％和21.7％(均P＜0.01)。UAP患者焦虑、抑郁程度与负性生活事件刺激量、消极应对分、CH分及血小板聚集率正相关(P＜0.05或P＜0.01)，与社会支持总分负相关(均P＜0.05)，血小板聚集率与负性生活事件刺激量、CH分亦显著正相关(均P＜0.01)。结论：UAP患者由于处于心理应激状态，表现焦虑、抑郁情绪障碍，血小板聚集功能增强，对疾病的发展和预后可能产生不利影响。
목적：탐토불은정성심교통(UAP)환자심리사회인소여혈소판취집공능적관계。방법：채용6개심리량표대46례UAP환자화46례건강인진행평정，병측정ADP유도적혈소판취집솔。결과：UAP조부성생활사건자격량、소겁응대、CH、초필화억욱적분급혈소판취집솔균고우대조조(균P＜0.01)，사회지지총분화적겁응대분저우대조조(균P＜0.01)，UAP조A형행위、초필급억욱분별점73.91％、82.6％화71.4％，고우대조조36.96％、34.8％화21.7％(균P＜0.01)。UAP환자초필、억욱정도여부성생활사건자격량、소겁응대분、CH분급혈소판취집솔정상관(P＜0.05혹P＜0.01)，여사회지지총분부상관(균P＜0.05)，혈소판취집솔여부성생활사건자격량、CH분역현저정상관(균P＜0.01)。결론：UAP환자유우처우심리응격상태，표현초필、억욱정서장애，혈소판취집공능증강，대질병적발전화예후가능산생불리영향。
Objective:To explore the relationship between psychosocial factors and platelet aggregation function in patients withunstable angina pectoris(UAP). Methods:Forty-six UAP patients and 46 healthy subjects were evaluated with 6 psychologi-cal scales,and their adenosine diphosphate(ADP)-induced platelet aggregation function was determined. Results: The scoresof negative life event stimuli,negative coping,CH, anxiety, depression and the rate of platelet aggregation function in UAPgroup were significantly higher than controls, whereas the scores of total social support and positive coping were markedlylower than controls(all P＜0.01). The prevalence of type A behavior, anxiety and depression in UAP group(73.91%,82.60% and 71.40% respectively)was higher than controls(36.96% ,34.80% and 21.70%respectively)(all P＜0.01).The scores of anxiety or depression in UAP group had a positive correlation with the scores of negative life event stimuli,negative coping,CH,anxiety,depression and the rate of platelet aggregation in UAP group (P＜0.05 or P＜0.01)and anegative correlation with the score of total social support( P ＜ 0.05). The rate of platelet aggregation had a positive correla-tion with the scores of negative life event stimuli and CH too ( all P ＜ 0.01 ). Conclusion: Emotional discord (such as anxietyor depression)and exaggerated platelet aggregation may affect the development and prognosis of UAP.