CAJ | 학술논문

人源性膀胱癌裸鼠模型与人类膀胱癌生长特性相似,能更好地模拟膀胱癌在人体内的自然生长过程及许多生物学行为.为深入研究人膀胱癌发生发展与转归机制,进行新型膀胱腔内生物免疫制剂和化疗药物临床前期评价,探索分子靶向治疗策略,建立人源性膀胱癌裸鼠模型具有重要的临床与科研意义.
인원성방광암라서모형여인류방광암생장특성상사,능경호지모의방광암재인체내적자연생장과정급허다생물학행위.위심입연구인방광암발생발전여전귀궤제,진행신형방광강내생물면역제제화화료약물림상전기평개,탐색분자파향치료책략,건립인원성방광암라서모형구유중요적림상여과연의의.
Nude mouse bearing human bladder cancer exhibits similar growth characteristics as human bladder cancer and therfore is a good simulation model in the research of the biological behaviors of human bladder cancer. To explore the initiation, development, prognosis and biological behavior of human bladder cancer,and to develop intravesical biological agents and antitumor drugs with improved strategies for prevention and treatment of bladder cancer, it is essential to establish human bladder tumor-bearing nude mice for basic and clinical researches. This is a review of the current status of the application of human bladder tumor-bearing nude mice.