国际遗传学杂志
國際遺傳學雜誌
국제유전학잡지
INTERNATIONAL JOURNAL OF GENETICS
2011年
1期
41-44,56
,共5页
ATF3%肿瘤%免疫调节%内分泌调节
ATF3%腫瘤%免疫調節%內分泌調節
ATF3%종류%면역조절%내분비조절
ATF3%Tumor%Immunoloregulation%Endocrine regulation
活化转录因子(activating transcription factor 3,ATF3)属于适应性反应基因,作为ATF/cAMP效应元件的结合蛋白,参与细胞为适应内外环境变化所发生的应激反应.ATF3可以根据靶基因和细胞环境的不同,激活或抑制相关基因表达,具有广泛的转录调节作用,在细胞周期、免疫调节、内分泌调节和肿瘤发生的过程中扮演重要角色.
活化轉錄因子(activating transcription factor 3,ATF3)屬于適應性反應基因,作為ATF/cAMP效應元件的結閤蛋白,參與細胞為適應內外環境變化所髮生的應激反應.ATF3可以根據靶基因和細胞環境的不同,激活或抑製相關基因錶達,具有廣汎的轉錄調節作用,在細胞週期、免疫調節、內分泌調節和腫瘤髮生的過程中扮縯重要角色.
활화전록인자(activating transcription factor 3,ATF3)속우괄응성반응기인,작위ATF/cAMP효응원건적결합단백,삼여세포위괄응내외배경변화소발생적응격반응.ATF3가이근거파기인화세포배경적불동,격활혹억제상관기인표체,구유엄범적전록조절작용,재세포주기、면역조절、내분비조절화종류발생적과정중분연중요각색.
Activating transcription factor 3 ( ATF3 ) is an adaptive-response gene that participates in cellular processes to adapt to extra- and/or intra-cellular changes, where it transduces signals from various receptors to activate or repress gene expression, depending on the promoter and cellular context. It is a member of the ATF/cyclic AMP response element-binding ( ATF/CREB ) family of transcription factors, which has a extensive transcriptional regulation. ATF3 plays an important role in cell cycle, immunoloregulation, endocrine regulation and tumorigenicity.
