国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2012年
7期
506-508
,共3页
阻塞性睡眠呼吸暂停低通气综合征%2型糖尿病%单核细胞趋化蛋白1%胱抑索C%持续气道正压通气
阻塞性睡眠呼吸暫停低通氣綜閤徵%2型糖尿病%單覈細胞趨化蛋白1%胱抑索C%持續氣道正壓通氣
조새성수면호흡잠정저통기종합정%2형당뇨병%단핵세포추화단백1%광억색C%지속기도정압통기
Obstructive sleep apnea hypopnea syndrome%Type 2 diabetes mellitus%Monocyte chemoattractant protein-1%Cystatin C%Continuous positive air pressure
目的 观察阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)合并2型糖尿病(T2DM)患者血清单核细胞趋化蛋白1(MCP-1)、胱抑素C(Cys C)的变化.方法 检测OSAHS合并T2DM患者、单纯OSAHS患者、单纯T2DM患者、正常对照者及20例中、重度OSAHS合并T2DM患者经鼻持续气道止压通气(nCPAP)治疗1个月后血清MCP-1、Cys C的水平.结果 OSAHS合并T2DM患者血清MCP-1、Cys C水平显著升高,且与反映睡眠呼吸暂停病情严重程度的指标有相关性.OSAHS合并T2DM患者nCPAP治疗后,血清MCP-1、Cys C水平明显下降,与治疗前相比差异有统计学意义.结论 MCP-1、Cys C可能通过缺氧、氧化应激、慢性炎症等途径参与OSAHS及其合并T2DM的发生.
目的 觀察阻塞性睡眠呼吸暫停低通氣綜閤徵(obstructive sleep apnea hypopnea syndrome,OSAHS)閤併2型糖尿病(T2DM)患者血清單覈細胞趨化蛋白1(MCP-1)、胱抑素C(Cys C)的變化.方法 檢測OSAHS閤併T2DM患者、單純OSAHS患者、單純T2DM患者、正常對照者及20例中、重度OSAHS閤併T2DM患者經鼻持續氣道止壓通氣(nCPAP)治療1箇月後血清MCP-1、Cys C的水平.結果 OSAHS閤併T2DM患者血清MCP-1、Cys C水平顯著升高,且與反映睡眠呼吸暫停病情嚴重程度的指標有相關性.OSAHS閤併T2DM患者nCPAP治療後,血清MCP-1、Cys C水平明顯下降,與治療前相比差異有統計學意義.結論 MCP-1、Cys C可能通過缺氧、氧化應激、慢性炎癥等途徑參與OSAHS及其閤併T2DM的髮生.
목적 관찰조새성수면호흡잠정저통기종합정(obstructive sleep apnea hypopnea syndrome,OSAHS)합병2형당뇨병(T2DM)환자혈청단핵세포추화단백1(MCP-1)、광억소C(Cys C)적변화.방법 검측OSAHS합병T2DM환자、단순OSAHS환자、단순T2DM환자、정상대조자급20례중、중도OSAHS합병T2DM환자경비지속기도지압통기(nCPAP)치료1개월후혈청MCP-1、Cys C적수평.결과 OSAHS합병T2DM환자혈청MCP-1、Cys C수평현저승고,차여반영수면호흡잠정병정엄중정도적지표유상관성.OSAHS합병T2DM환자nCPAP치료후,혈청MCP-1、Cys C수평명현하강,여치료전상비차이유통계학의의.결론 MCP-1、Cys C가능통과결양、양화응격、만성염증등도경삼여OSAHS급기합병T2DM적발생.
Objective To explore the changes of levels of serum Monocyte chemoattractant protein-1 (MCP-1) and Cystatin C (Cys C) in patients with obstructive sleep apnea-bypopnea syndrome (OSAHS)complicated by type 2 diabetes.Methods The levels of serum MCP-1 and Cys C were measured in 25 patients with OSAHS complicated by type 2 diabetes,25 patients with OSAHS,25 patients with type 2 diabetes,25 healthy subjects,20 patients with OSAHS complicated by type 2 diabetes who accepted nCPAP treatment for 1 month.Results The levels of serum MCP-1 and Cys C were significantly higher in patients with OSAHS complicated by type 2 diabetes,and were corrrlated significantly with the index of polysomnography which reflect the severity of obstructive sleep apnea.After the nCPAP treatment for 1 month,the levels of serum MCP-1 and Cys C were significantly lower than before.Conclusions MCP-1 and Cys C may through hypoxia,oxidative stress,chronic inflammation involved in the development of OSAHS and OSAHS complicated by type 2 diabetes.
