CAJ | 학술논문

目的探讨复合干扰素(comb interferon,CITF)联合利巴韦林治疗复发及无应答慢性丙型肝炎的效果.方法对74例干扰素治疗后复发或无应答的慢性丙型肝炎患者,用复合干扰素15 μg,每周3次,皮下注射,疗程24周,观察治疗过程中、治疗结束时及停药半年后的临床症状、体征、ALT、丙型肝炎病毒持续免疫应答率及不良反应情况.结果 72例患者完成治疗,复发组和无应答组治疗结束后HCV.RNA持续阴转率分别为73%和37%(P＜0.05),未发现严重不良反应.结论复合干扰素联合利巴韦林用于治疗复发或无应答的慢性丙型肝炎有一定的疗效.
목적 탐토복합간우소(comb interferon,CITF)연합리파위림치료복발급무응답만성병형간염적효과.방법 대74례간우소치료후복발혹무응답적만성병형간염환자,용복합간우소15 μg,매주3차,피하주사,료정24주,관찰치료과정중、치료결속시급정약반년후적림상증상、체정、ALT、병형간염병독지속면역응답솔급불량반응정황.결과 72례환자완성치료,복발조화무응답조치료결속후HCV.RNA지속음전솔분별위73%화37%(P＜0.05),미발현엄중불량반응.결론 복합간우소연합리파위림용우치료복발혹무응답적만성병형간염유일정적료효.
Objective To investigate the effect of comb interferon( comb interferon CITF) uniting virazole to cure recurring or non-responding chronic hepatitis C.Methods Hypodermic comb "interferon 15μg,3 times every week,subcutaneously injected,24 weeks course of treatment was adminstered to 74 patients of recurring or non-responding chronic hepatitis C.Clinical symptom,physical sign,ALT,hepatovirus continual response rate and the condition of adverse effect were observed during treatment,chron-culminate,follow to 6 months' withdrawl.Results 72 patients accomplished treatment,HCV-RNA of recurring group and non-responding group to continual negative change rate were 73% and 37% (P＜0.05)after treatment termination,without severity adverse reaction being found.Condusion Comb interferon 15 μg/d combining virazole 900mg/d have better curative effect in curing recurring or nonresponding chronic hepatitis C.