CAJ | 학술논문

目的探讨多项肿瘤标志物联合检测在原发性肝癌中的诊断价值及建立判别方程.方法采用蛋白芯片技术,检测2003年11月至2006年4月大坪医院收治的98例原发性肝癌患者(肝癌组)、67例良性肝病患者(肝病组)、46例健康体检者(对照组)血清中的12项肿瘤标志物,并在肝癌组与肝病组患者之间建立判别方程.采用方差分析和X2检验对检测结果进行分析.结果肝癌组中87例患者肿瘤标志物呈阳性表达(89%),肝病组中有13例呈阳性表达(19%),对照组中有2例呈阳性表达(4%).3组中的AFP、CEA、铁蛋白、CA19-9和CA125检测结果比较,差异有统计学意义(F=59.530,40.472,31.708,75.897,153.066,P<0.05).联合检测这5项指标,肝癌临床诊断符合率提高为89%,明显高于单项AFP检测的64%(X2=16.362,P<0.05).所建判别方程的判断准确率为90%.结论多项肿瘤标志物联合检测优于单独AFP检测,可用于对肝癌高危人群的筛查及原发性肝癌的早期诊断.
목적 탐토다항종류표지물연합검측재원발성간암중적진단개치급건립판별방정.방법 채용단백심편기술,검측2003년11월지2006년4월대평의원수치적98례원발성간암환자(간암조)、67례량성간병환자(간병조)、46례건강체검자(대조조)혈청중적12항종류표지물,병재간암조여간병조환자지간건립판별방정.채용방차분석화X2검험대검측결과진행분석.결과 간암조중87례환자종류표지물정양성표체(89%),간병조중유13례정양성표체(19%),대조조중유2례정양성표체(4%).3조중적AFP、CEA、철단백、CA19-9화CA125검측결과비교,차이유통계학의의(F=59.530,40.472,31.708,75.897,153.066,P<0.05).연합검측저5항지표,간암림상진단부합솔제고위89%,명현고우단항AFP검측적64%(X2=16.362,P<0.05).소건판별방정적판단준학솔위90%.결론 다항종류표지물연합검측우우단독AFP검측,가용우대간암고위인군적사사급원발성간암적조기진단.
Objective To investigate the value of combined detection of multi-tumor markers in the diagnosis of primary hepatocellular carcinoma (HCC) and to establish the discriminant equation. Methods Using a protein chip, 12 tumor markers in the serum from 98 patients with HCC and 67 patients with benign liver diseasewho had been admitted to Daping Hospital from November 2003 to April 2006, and 46 healthy individuals during he same period were analyzed. A discriminant equation was established to discriminate primary HCC from benign liver diseases. All the data were processed by variance analysis and chi-square test. Results The positive rates of the tumor markers were 89% (87/98) in patients with primary HCC, 19% (13/67) in patients with benign liver disease and 4% (2/46) in healthy individuals. There was statistical difference in the serum level of alpha-fetoprotein (AFP), eareinoembryonic antigen (CEA), ferritin (FER), CA19-9 and CA125 among the 3 groups (F =59.530, 40.472, 31.708, 75. 897, 153.066, P <0.05). Combined detection of AFP, CEA, FER, CA19-9 and CA125 improved the diagnostic accordance rate to 89%, which was significandy higher than the diagnostic accordance rate (64%) when only AFP was detected (X2 = 16.362, P <0.05). The accuracy of the discriminant equation was 90%. Conclusions Combined detection of multi-tumor markers is superior to AFP detection. Combined detection of multi-tumor markers can be used in screening of the HCC patients in HCC high risk population and in the early diagnosis of primary HCC.