熵指数监测脑电信号用于全身麻醉深度调控的临床研究
적지수감측뇌전신호용우전신마취심도조공적림상연구
Entropy of EEG in regulating and controlling the depth of general anesthesia
  • 万方数据
    中国实用医刊 중국실용의간
    CENTRAL PLAINS MEDICAL JOURNAL
    2012年 7期 43-46 ,共4页

    邢书军%刘文奇%刘卫校%李景信

    형서군%류문기%류위교%리경신

    熵指数%状态熵%反应熵%脑电信号%全麻深度%靶控 熵指數%狀態熵%反應熵%腦電信號%全痳深度%靶控
    적지수%상태적%반응적%뇌전신호%전마심도%파공
    Entropy index%State entropy%Response entropy%EEG%Depth of general anesthesia%Target controlled
    目的 研究熵指数(entropy)监测脑电信号指导全麻深度调控的有效性及特点.方法 选全麻下行胆囊切除术患者100例,将患者随机分为两组,每组50例:G组(n=50)为对照组暨无熵指数监测组,根据传统的血压、心率等血流动力学指标调节靶控泵上异丙酚的模拟靶控浓度；E组(n=50)为熵指数[状态熵(state entropy,SE)和反应熵( response entropy,RE)]指导组,通过维持熵指数值在40～60调节异丙酚靶浓度维持适宜的麻醉深度.两组患者均采用异丙酚加瑞芬太尼联合靶控输注( TCI)全静脉全麻,采用TCI-I双通道麻醉靶控输注泵,诱导时设定异丙酚模拟血浆靶浓度3 μg／ml,瑞芬太尼模拟血浆靶浓度7 ng/ml,意识消失后给予维库溴按0.1mg/kg辅助气管内插管接呼吸机行机械通气.G组根据术中患者血压或心率变化调节麻醉深度,E组患者根据熵指数变化调节麻醉深度.记录两组患者麻醉及手术期间血流动力学指标、麻醉药物用量、术毕清醒时间及拔管时间.E组记录麻醉诱导后、气管插管时、术中及手术结束麻醉苏醒期的熵指数(SE和RE),术毕询问患者是否发生术中知晓,记录麻醉苏醒期患者意识状态的镇静/警觉(OAA/S)评分,记录对应OAA/S评分的RE、SE数值,对熵指数( SE、RE)和麻醉苏醒期(OAA/S)评分进行相关性分析.结果 E组患者SE基础值低于RE,诱导后RE、SE均下降,SE较RE下降明显,低于基础水平,术中血压、心率变化比较差异无统计学意义(胆囊切除时值较切皮时值,P＞ 0.05),恢复期明显回升但未能回到基础水平(P＜0.0l).诱导后血压较基础值显著降低(P＜0.01),与熵指数变化值相关性强.麻醉用药量比较:G组异丙酚的用量高于E组,差异有统计学意义(P＜0.05).E组患者与G组相比,苏醒时间明显减少,差异有统计学意义(P＜0.05)；E组自主呼吸恢复快,拔管时间短,且患者定向力恢复迅速.熵指数与麻醉苏醒期OAA/S评分具有良好相关性(P＜0.05).所有患者术后随访均未发生术中知晓.结论 熵指数可准确监测脑电信号,及时指导全麻深度调控,值得临床推广运用.
    목적 연구적지수(entropy)감측뇌전신호지도전마심도조공적유효성급특점.방법 선전마하행담낭절제술환자100례,장환자수궤분위량조,매조50례:G조(n=50)위대조조기무적지수감측조,근거전통적혈압、심솔등혈류동역학지표조절파공빙상이병분적모의파공농도；E조(n=50)위적지수[상태적(state entropy,SE)화반응적( response entropy,RE)]지도조,통과유지적지수치재40～60조절이병분파농도유지괄의적마취심도.량조환자균채용이병분가서분태니연합파공수주( TCI)전정맥전마,채용TCI-I쌍통도마취파공수주빙,유도시설정이병분모의혈장파농도3 μg／ml,서분태니모의혈장파농도7 ng/ml,의식소실후급여유고추안0.1mg/kg보조기관내삽관접호흡궤행궤계통기.G조근거술중환자혈압혹심솔변화조절마취심도,E조환자근거적지수변화조절마취심도.기록량조환자마취급수술기간혈류동역학지표、마취약물용량、술필청성시간급발관시간.E조기록마취유도후、기관삽관시、술중급수술결속마취소성기적적지수(SE화RE),술필순문환자시부발생술중지효,기록마취소성기환자의식상태적진정/경각(OAA/S)평분,기록대응OAA/S평분적RE、SE수치,대적지수( SE、RE)화마취소성기(OAA/S)평분진행상관성분석.결과 E조환자SE기출치저우RE,유도후RE、SE균하강,SE교RE하강명현,저우기출수평,술중혈압、심솔변화비교차이무통계학의의(담낭절제시치교절피시치,P＞ 0.05),회복기명현회승단미능회도기출수평(P＜0.0l).유도후혈압교기출치현저강저(P＜0.01),여적지수변화치상관성강.마취용약량비교:G조이병분적용량고우E조,차이유통계학의의(P＜0.05).E조환자여G조상비,소성시간명현감소,차이유통계학의의(P＜0.05)；E조자주호흡회복쾌,발관시간단,차환자정향력회복신속.적지수여마취소성기OAA/S평분구유량호상관성(P＜0.05).소유환자술후수방균미발생술중지효.결론 적지수가준학감측뇌전신호,급시지도전마심도조공,치득림상추엄운용.
    Objective To investigate the characteristic and efficacy of Entropy of EEG in regulating and controlling the depth of general anesthesia.Methods One hundred cases who received cholecystectomy under general anesthesia,were included in this study.They were randomly divided into group G and group E( state entropy and response entropy group).In group G,adjustment of simulated concentration of propofol on target-controlled pump was based on the alteration of blood pressure,heart rate and other hemodynamic parameters.In group E,the control of appropriate depth of general anesthesia was through maintaining theentropy indes value between 40 and 60.Intravenous infusion of propofal combined with remifentanil was adopted for anesthesia induction.The simulated target plasma concentration of propofol was setted at 3 μg/ml while remifentanil at 7 ng/ml.Hemodynamics parameter,sober time and extubation time during anesthesia and surgery,anesthetic drug consuption and the entropyindex(SE and RE) were recorded for analysis.Results Baseline values of SE were lower than RE in group E.Both RE and SE decreased after induction,however,SE decreased more significantly compared with RE and was lower than the basic level (P ＜ 0.01 ).Blood pressure declined obviously after induction and was lower than the baseline blood pressure ( P ＜ 0.0l ),and had a strong correlation with the alteration of entropyindex value.The consume of propofol in group G was more than that of group E,the difference was statistically significance (P ＜ 0.05 ).Recovery time in group E significantly reduced compared with group G (P ＜ 0.05 ).Patients in group E can more rapidly recoverspontaneous breathing,had shorter extubation time and promptly recovered orientation.There was good correlation between the entropy index and OAA/S score (P ＜ 0.05 ).All patients had no intraoperative awareness.Conclusions Entropy of EEG can accuratly regulate and controll the depth of general anesthesia and was worthy of clinical use.
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