CAJ | 학술논문

目的：提取分离穿心莲抗血小板聚集活性物质。方法：用有机溶剂萃取、化学分离和硅胶柱层析法对穿心莲抗血小板聚集部位逐级分离，同时用样本对ADP诱导的血小板聚集抑制作用作活性比较，筛选出活性强的组份继续分离。结果：氯仿提取部位中的酸性组份(F021)有较强的抗血小板聚集活性，且其中F0212和F0214组份可用作分离抗血小板聚集的单体化合物。结论：穿心莲抗血小板聚集活性物质可以用逐级分离方法制备。
목적：제취분리천심련항혈소판취집활성물질。방법：용유궤용제췌취、화학분리화규효주층석법대천심련항혈소판취집부위축급분리，동시용양본대ADP유도적혈소판취집억제작용작활성비교，사선출활성강적조빈계속분리。결과：록방제취부위중적산성조빈(F021)유교강적항혈소판취집활성，차기중F0212화F0214조빈가용작분리항혈소판취집적단체화합물。결론：천심련항혈소판취집활성물질가이용축급분리방법제비。
Objective:This paper was designed to reveal the active ingredients to inhibit platelet aggregation in Andregraphis Paniculata Ness (APN).　Methods:Separating the active component parts of APN on the antiplatelet aggretion by extraction of organic solvent, chemical separation and silica column chromatography step by step, simultaneously comparing the effect of samples in APN on the antiplatelet aggretion induced by ADP, so that we can find the more active components.　Results:We find the acid components in chlorlform parts (F021) show more active on the antiplatelet aggretion, farthermore we think we can obstain pure chemicals on the antiplatelet aggretion in F0212 and F0214.　Conclusions:The active components on antiplatelet aggretion of APN can be prepared by separation step by step.