CAJ | 학술논문

应用循环伏安法和微分脉冲阳极溶出伏安法在玻碳电极上对氢溴酸右美沙芬的伏安行为进行了研究.实验结果表明,在pH 6.5的B-R(Britton-Robinson)缓冲底液中,氢溴酸右美沙芬在+1.01 V(vs.Ag/AgCl)处有一明显的氧化峰,在4.0×10~(-6)～8.0×10~(-5) mol/L范围内与峰电流呈良好的线性关系(r=0.995 1),检出限为5.6×10~(-7) mol/L.用该方法对氢溴酸右美沙芬片进行了测定,回收率为98.6%～102.9%,结果令人满意,还对其电极反应机理进行了初步探讨.
응용순배복안법화미분맥충양겁용출복안법재파탄전겁상대경추산우미사분적복안행위진행료연구.실험결과표명,재pH 6.5적B-R(Britton-Robinson)완충저액중,경추산우미사분재+1.01 V(vs.Ag/AgCl)처유일명현적양화봉,재4.0×10~(-6)～8.0×10~(-5) mol/L범위내여봉전류정량호적선성관계(r=0.995 1),검출한위5.6×10~(-7) mol/L.용해방법대경추산우미사분편진행료측정,회수솔위98.6%～102.9%,결과령인만의,환대기전겁반응궤리진행료초보탐토.
The voltammetric behavior of dextromethorphan hydrobromide was studied by cyclic voltammetry and differential pulse anodic stripping voltammetry using a glass carbon electrode.In a Britton-Robinson(B-R) buffer solution with a pH value of 6.5,the oxidation peak potential was at +1.01 V(vs.Ag/AgCl).There was a good linear relationship between the peak current and dextromethorphan hydrobromide concentration in the range of 4.0×10~(-6)～8.0×10~(-5) mol/L,and the detection limit was 5.6×10~(-7) mol/L.The detected recovery of dextromethorphan hydrobromide tablets with differential pulse anodic stripping voltammetry was in the range of 98.6%～102.9%,the results were satisfactory for application.Furthermore,the electrode reaction mechanism was preliminarily discussed.