CAJ | 학술논문

肾小球系膜增生是多种肾脏疾病的基本病理过程,系膜增生性肾小球肾炎(MsPGN)是常见的病理类型.目前MsPGN发病机制仍不清楚,近年来以fractalkine、白细胞介素、转化生长因子-β等为代表的细胞因子逐渐成为MsPGN发病机制的研究热点,多种细胞因子在MsPGN发生发展中起重要作用.目前在MsPGN治疗上也取得一定的进展,对吗替麦考酚酯有了更深的认识,其在难治性肾病综合征患儿的治疗中取得了良好效果.
신소구계막증생시다충신장질병적기본병리과정,계막증생성신소구신염(MsPGN)시상견적병리류형.목전MsPGN발병궤제잉불청초,근년래이fractalkine、백세포개소、전화생장인자-β등위대표적세포인자축점성위MsPGN발병궤제적연구열점,다충세포인자재MsPGN발생발전중기중요작용.목전재MsPGN치료상야취득일정적진전,대마체맥고분지유료경심적인식,기재난치성신병종합정환인적치료중취득료량호효과.
Mesangial proliferation is a basic pathologic process of many kidney diseases,mesangial proliferative glomerulonephritis(MsPGN) is the common pathological type.The pathogenesis of MsPGN still remains unclear.Recently,cytokines of fractalkine,interleukin and TGF-β gradually become hotspot in the pathogenesis of MsPGN.Studies shows that a variety of cytokines play an important roles in the development of MsPGN and the mechanism has been gradually clarified.Certain progress has been made in treatment,and more profound understanding of mycophenolate mofetil has been received,the treatment of the MsPGN as manifestations with refractory nephrotic syndrome has been achieved good effect.This review is based on the recent years of the primary non-IgA MsPGN progress.