CAJ | 학술논문

目的探讨大鼠Allen脊髓损伤模型动物死亡的原因.方法选用120只Wistar成年大鼠,采用Allen打击模型(25 g·cm),在T10段造成急性脊髓损伤,对损伤后死亡动物进行统计和解剖.结果死亡25例,死亡率为21%,其中5只死于苏醒前,解剖未发现异常;12只死于损伤后3 d内,3只死于损伤后3～7 d,解剖发现肺部均有出血、水肿.部分动物有膀胱积血;3只死于8～14 d,1只死于损伤后15～21 d,解剖发现分别有肺部感染和泌尿系感染.3周后无死亡.结论大鼠Allen脊髓损伤模型动物早期死亡的主要原因是肺淤血和肺水肿,晚期死亡的主要原因是肺部和泌尿系感染.
목적 탐토대서Allen척수손상모형동물사망적원인.방법 선용120지Wistar성년대서,채용Allen타격모형(25 g·cm),재T10단조성급성척수손상,대손상후사망동물진행통계화해부.결과 사망25례,사망솔위21%,기중5지사우소성전,해부미발현이상;12지사우손상후3 d내,3지사우손상후3～7 d,해부발현폐부균유출혈、수종.부분동물유방광적혈;3지사우8～14 d,1지사우손상후15～21 d,해부발현분별유폐부감염화비뇨계감염.3주후무사망.결론대서Allen척수손상모형동물조기사망적주요원인시폐어혈화폐수종,만기사망적주요원인시폐부화비뇨계감염.
Objective To investigate the causes for death in rats after spinal cord injury.Methods A total of 120 adult Wister rats were selected for the study. The animal model with acute spinal injury at T10 was established by using Allen' s combat (25 g · cm). The dissection analysis was performed in death rats. Results Of all, 25 patients died, with mortality rate of 21%. Of death rats, five rats were died before awakening, with no abnormal anatomy; 12 rats died within three days after injury and three died of injuries 3-7days injury. Anatomy found pulmonary bleeding and edema, even hematocele bladder in some rats. There were three rats died within 1-2 weeks, one died of injury only after 2-3 weeks, with lung infection and urinary tract infection. There was no death after three weeks. Conclusions The early causes for death of rats with spinal cord injury is mainly due to lung congestion and pulmonary edema, whereas the leading cause of late death of rats is pulmonary and urinary tract infection.